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How to get fromLancaster to Hyannisby train, bus, car, plane, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Lancaster to Hyannis by train, bus, car, plane, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus via Boston

    best
    1. Take the train from Elizabethtown Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    12h 15m
    $159–310

  2. Drive 395 mi

    cheapest
    1. Drive from Lancaster to Hyanniscar car 395 mi
    7h 52m
    $73–105

  3. Train, bus

    1. Take the train from Elizabethtown Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the bus from Port Authority Bus Terminal to Peter Pan Bus Terminalbus bus
    3. Take the bus from Providence Bus Terminal to Hyannis Transportation Centerbus bus
    13h 15m
    $107–260

  4. Train to Philadelphia International Airport, fly to Barnstable Municipal Airport

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Barnstable Municipal Airport (HYA)plane plane PHL - HYA
    8h 16m
    $111–609

  5. Bus

    1. Take the bus from Harrisburg Bus Station to Port Authority Bus Terminalbus bus
    2. Take the bus from New York Midtown to Bostonbus bus
    3. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus
    16h 39m
    $91–186

  6. Fly Harrisburg International Airport to Boston Logan Airport, bus

    1. Fly from Harrisburg International Airport (MDT) to Boston Logan Airport (BOS)plane plane MDT - BOS
    2. Take the bus from Logan International Airport to Hyannis Transportation Centerbus bus
    8h 43m
    $135–703

  7. Train to John F. Kennedy International Airport, fly to Barnstable Municipal Airport

    1. Take the train from Elizabethtown Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Barnstable Municipal Airport (HYA)plane plane JFK - HYA
    9h 34m
    $421–784

  8. Train to Philadelphia International Airport, fly to Boston Logan Airport, bus

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Boston Logan Airport (BOS)plane plane PHL - BOS
    3. Take the bus from Logan International Airport to Hyannis Transportation Centerbus bus
    9h 15m
    $229–1,049

  9. Train, train to Ronald Reagan Washington National Airport, fly to Barnstable Municipal Airport

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Barnstable Municipal Airport (HYA)plane plane DCA - HYA
    8h 46m
    $172–1,413

Lancaster to Hyannis by bus and train

Calendar27Weekly Services
Duration12h 15mAverage Duration
Ticket$159Cheapest Price
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Questions & Answers

Map of how to get from Lancaster to Hyannis.ExpandLaunch map view
  • Distance: 502.4 mi
  • Duration: 12h 15m

What companies run services between Lancaster, PA, USA and Hyannis, MA, USA?

You can take a bus from Queen St. Station to Hyannis Transportation Center via AMTRAK ETown, Elizabethtown Amtrak Station, Harrisburg, Harrisburg Bus Station, Port Authority Bus Terminal, New York Midtown, Boston, and Boston South Station in around 16h 39m.

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Train operators
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