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How to get fromLancaster to Knoxvilleby plane, train, bus, car, subway, or bus (Flixbus)

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There are 10 ways to get from Lancaster to Knoxville by plane, train, bus, car, subway, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Harrisburg International Airport to Mcghee Tyson Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS)plane plane MDT - TYS
    8h 30m
    $291–1,383

  2. Drive 554.3 mi

    cheapest
    1. Drive from Lancaster to Knoxvillecar car 554.3 mi
    9h 49m
    $102–147

  3. Train, bus via Farragut

    1. Take the train from Elizabethtown Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    18h 47m
    $239–368

  4. Line 18 bus, train to Philadelphia International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Queen St. Station to AMTRAK ETownbus bus
    2. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane plane PHL - TYS
    7h 24m

  5. Train, train to Baltimore-Washington International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Mcghee Tyson Airport (TYS)plane plane BWI - TYS
    8h 23m
    $226–1,476

  6. Train, train to Ronald Reagan Washington National Airport, fly to Mcghee Tyson Airport

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Mcghee Tyson Airport (TYS)plane plane DCA - TYS
    9h 13m
    $286–1,783

  7. Train to Philadelphia International Airport, fly to Asheville Regional Airport, drive

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Asheville Regional Airport (AVL)plane plane PHL - AVL
    3. Drive from Asheville-Airport-AVL to Knoxvillecar car
    9h 23m
    $137–584

  8. Train, subway to Washington Dulles International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the subway from Farragut West, Blue/Orange/Silver Line Track 2 Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    4. Fly from Washington Dulles International Airport (IAD) to Mcghee Tyson Airport (TYS)plane plane IAD - TYS
    9h 39m
    $216–1,382

  9. Train, bus

    1. Take the train from Elizabethtown Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Keystone Service / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    18h 49m
    $194–278

  10. Bus

    1. Take the bus from Harrisburg Bus Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    24h 56m
    $139–186

Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) flights

Calendar99Weekly Planes
Duration4h 55mAverage Duration
Ticket$233Cheapest Price
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Questions & Answers

Map of how to get from Lancaster to Knoxville.ExpandLaunch map view
  • Distance: 559.6 mi
  • Duration: 8h 30m

What companies run services between Lancaster, PA, USA and Knoxville, TN, USA?

United Airlines, American Airlines, and two other airlines fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Queen St. Station to Knoxville Station Hall of Fame via AMTRAK ETown, Elizabethtown Amtrak Station, Harrisburg, Harrisburg Bus Station, New York, NY, Knoxville, TN, Walmart, and Fountain City Superstop in around 24h 56m.

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