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How to get fromLancaster to St. Louisby train, plane, bus (Greyhound), train (Amtrak), car, or subway

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There are 9 ways to get from Lancaster to St. Louis by train, plane, bus (Greyhound), train (Amtrak), car, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly

    best
    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    8h 5m
    $184–862

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Harrisburg Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    21h 24m
    $126–251

  3. Train (Amtrak)

    1. Take the train from Elizabethtown Amtrak Station to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    24h 31m
    $325–682

  4. Drive 815.1 mi

    1. Drive from Lancaster to St. Louiscar car 815.1 mi
    13h 58m
    $149–215

  5. Fly from Harrisburg International Airport

    1. Fly from Harrisburg International Airport (MDT) to Lambert–St. Louis International Airport (STL)plane plane MDT - STL
    9h 21m
    $250–1,216

  6. Train, train to Baltimore-Washington International Airport, fly

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    9h 19m
    $185–1,359

  7. Train, train to Ronald Reagan Washington National Airport, fly

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    10h 1m
    $225–1,096

  8. Train, train to Newark Liberty International Airport, fly

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    3. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    9h 58m
    $426–914

  9. Train, subway to Washington Dulles International Airport, fly

    1. Take the train from Elizabethtown Amtrak Station to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Take the subway from Farragut West, Blue/Orange/Silver Line Track 2 Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    4. Fly from Washington Dulles International Airport (IAD) to Lambert–St. Louis International Airport (STL)plane plane IAD - STL
    10h 45m
    $245–1,715

Lancaster to St. Louis by bus and train (Greyhound)

Calendar14Weekly Services
Duration21h 24mAverage Duration
Ticket$126Cheapest Price
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Questions & Answers

Map of how to get from Lancaster to St. Louis.ExpandLaunch map view
  • Distance: 940.7 mi
  • Duration: 8h 5m

What companies run services between Lancaster, PA, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from Harrisburg Bus Station to St Louis Bus Station twice daily. Tickets cost $120–240 and the journey takes 18h 5m. Alternatively, you can take a bus from W. Walnut & N. Mary St. to St. Louis via AMTRAK ETown, Elizabethtown Amtrak Station, Pittsburgh Amtrak Station, and Chicago Union Station in around 24h 31m.

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