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How to get fromLancaster (Station) to St. Louisby train, plane, bus, train (Amtrak), or car

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There are 8 ways to get from Lancaster (Station) to St. Louis by train, plane, bus, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Philadelphia International Airport, fly

    best
    1. Take the train from Lancaster to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    5h 46m
    $177–850

  2. Train, bus

    cheapest
    1. Take the train from Lancaster to Harrisburgtrain train Pennsylvanian / ...
    2. Take the bus from Harrisburg Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    19h 40m
    $131–253

  3. Train (Amtrak)

    1. Take the train from Lancaster to Pittsburgh Amtrak Stationtrain train
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    22h 45m
    $324–694

  4. Drive 814 mi

    1. Drive from Lancaster (Station) to St. Louiscar car 814 mi
    13h 55m
    $149–215

  5. Train to Harrisburg International Airport, fly

    1. Take the train from Lancaster to Harrisburgtrain train
    2. Fly from Harrisburg International Airport (MDT) to Lambert–St. Louis International Airport (STL)plane plane MDT - STL
    7h 37m
    $255–1,228

  6. Train, train to Baltimore-Washington International Airport, fly

    1. Take the train from Lancaster to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    7h 1m
    $178–1,347

  7. Train, train to Ronald Reagan Washington National Airport, fly

    1. Take the train from Lancaster to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Washington Union Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    7h 43m
    $218–1,084

  8. Train, train to Newark Liberty International Airport, fly

    1. Take the train from Lancaster to 30th Street Stationtrain train
    2. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    3. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    7h 38m
    $419–902

Lancaster (Station) to St. Louis by train and bus

Calendar28Weekly Services
Duration19h 40mAverage Duration
Ticket$131Cheapest Price
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Questions & Answers

Map of how to get from Lancaster (Station) to St. Louis.ExpandLaunch map view
  • Distance: 899.7 mi
  • Duration: 5h 46m

What companies run services between Lancaster (Station), PA, USA and St. Louis, MO, USA?

You can take a train from Lancaster to St. Louis via Pittsburgh Amtrak Station and Chicago Union Station in around 22h 45m.

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