There are 7 ways to get from Lansing to Mayo Clinic by plane, bus (Amtrak), train, bus, car, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Capital Region International Airport
best- Fly from Capital Region International Airport (LAN) to Rochester (RST)plane LAN - RST
6h 22m$100–562Bus
- Take the bus from East Lansing Amtrak Station to Chicago Union Stationbus
- Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus
- Take the bus from Madison to Rochesterbus
15h 27m$138–223Train, bus
- Take the train from East Lansing Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to St. Paul-Minneapolistrain
- Take the bus from St. Paul to Rochesterbus
16h 32m$181–403Drive 561.3 mi
- Drive from Lansing to Mayo Cliniccar 561.3 mi
9h 21m$103–148Bus to Bishop International Airport, fly
- Take the bus from Lansing to Flintbus
- Fly from Bishop International Airport (FNT) to Rochester (RST)plane FNT - RST
8h 7m$107–470Train, bus via Madison
- Take the train from East Lansing Amtrak Station to Chicago Union Stationtrain
- Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus
- Take the bus from Madison to Rochesterbus
15h 27m$128–253Bus via South Haven
- Take the bus from CATA Intermodal Downtown to South Haven Potatoes Plusbus
- Take the bus from South Haven to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Madisonbus
- Take the bus from Madison to Rochesterbus
16h 38m$115–190
Lansing to Mayo Clinic by bus and foot
Comparing Your Travel Options
The cheapest way to get from Lansing to Mayo Clinic is to drive which costs $100 - $150 and takes 9h 21m.
The fastest way to get from Lansing to Mayo Clinic is to fly which takes 6h 22m and costs $95 - $600.
No, there is no direct bus from Lansing to Mayo Clinic. However, there are services departing from NBD Grand Ave before E Allegan St and arriving at Rochester via WBD Gr. River past MAC AVE, East Lansing Amtrak Station, W Jackson Blvd, after S Clinton St and Madison. The journey, including transfers, takes approximately 15h 27m.
The distance between Lansing and Mayo Clinic is 421 miles. The road distance is 564.6 miles.
The best way to get from Lansing to Mayo Clinic without a car is to bus which takes 15h 27m and costs $130 - $230.
It takes approximately 6h 22m to get from Lansing to Mayo Clinic, including transfers.
Lansing to Mayo Clinic bus services, operated by Amtrak, depart from East Lansing Amtrak Station.
The best way to get from Lansing to Mayo Clinic is to fly which takes 6h 22m and costs $95 - $600. Alternatively, you can bus, which costs $130 - $230 and takes 15h 27m.
Lansing to Mayo Clinic bus services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Lansing to Mayo Clinic is 565 miles. It takes approximately 9h 21m to drive from Lansing to Mayo Clinic.
What companies run services between Lansing, MI, USA and Mayo Clinic, MN, USA?
American Airlines, United Airlines, and Delta fly from Capital Region International Airport (LAN) to Rochester (RST) 4 times a day. Alternatively, you can take a bus from NBD Grand Ave before E Allegan St to Mayo Clinic via EBD Gr. River past Abbot Rd, WBD Gr. River past MAC AVE, East Lansing Amtrak Station, Chicago Union Station, W Jackson Blvd, after S Clinton St, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 15h 27m.
- Website
- aa.com
Flights from Capital Region International Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 5h 25m
- When
- Every day
- Estimated price
- $80–500
Flights from Bishop International Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 5h 57m
- When
- Every day
- Estimated price
- $60–360
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from East Lansing Amtrak Station to Chicago Union Station
- Ave. Duration
- 3h 51m
- Frequency
- Once daily
- Estimated price
- $50–120
- Website
- Amtrak
Train from Chicago Union Station to St. Paul-Minneapolis
- Ave. Duration
- 7h 31m
- Frequency
- 3 times a day
- Estimated price
- $100–240
- Website
- Amtrak
Train from East Lansing Amtrak Station to Chicago Union Station
- Ave. Duration
- 3h 51m
- Frequency
- Once daily
- Estimated price
- $50–120
- Website
- Amtrak
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from East Lansing Amtrak Station to Chicago Union Station
- Ave. Duration
- 3h 51m
- Frequency
- Once a week
- Estimated price
- $60–90
- Website
- Amtrak
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Booking & Getting There
There are 79+ hotels available in Mayo Clinic.





