There are 4 ways to get from Las Vegas to Otay Mesa by plane, tram, bus, car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, tram
best- Fly from Harry Reid International Airport (LAS) to San Diego International Airport (SAN)plane LAS - SAN
- Take the tram from Civic Center Station to Iris Avenue Stationtram
4h 1m$100–578Drive 346.6 mi
cheapest- Drive from Las Vegas to Otay Mesacar 346.6 mi
5h 43m$64–92Bus
- Take the bus from Las Vegas to San Ysidro, CAbus Las Vegas
7h 36m$84–111Bus via Las Vegas, Gilespie Street (South Strip Transit Terminal) (Flixbus)
- Take the bus from Las Vegas Strip to San Ysidro Bus Terminalbus FlixBus 2037
12h 25m$73–134
Las Vegas to Otay Mesa by bus and tram
Questions & Answers
The cheapest way to get from Las Vegas to Otay Mesa is to drive which costs $60 - $95 and takes 5h 43m.
The fastest way to get from Las Vegas to Otay Mesa is to fly and tram which takes 4h 1m and costs $100 - $600.
No, there is no direct bus from Las Vegas to Otay Mesa. However, there are services departing from Las Vegas and arriving at Otay Mesa Rd & Cactus Rd via Iris Avenue Transit Center. The journey, including transfers, takes approximately 7h 36m.
The distance between Las Vegas and Otay Mesa is 288 miles. The road distance is 348.7 miles.
The best way to get from Las Vegas to Otay Mesa without a car is to bus which takes 7h 36m and costs $80 - $120.
It takes approximately 4h 1m to get from Las Vegas to Otay Mesa, including transfers.
Las Vegas to Otay Mesa bus services, operated by Tufesa, depart from Las Vegas station.
Las Vegas to Otay Mesa bus services, operated by Tufesa, arrive at San Ysidro, CA station.
Yes, the driving distance between Las Vegas to Otay Mesa is 349 miles. It takes approximately 5h 43m to drive from Las Vegas to Otay Mesa.
There are 572+ hotels available in Otay Mesa.
What companies run services between Las Vegas, NV, USA and Otay Mesa, CA, USA?
Tufesa operates a bus from Las Vegas to San Ysidro, CA twice daily. Tickets cost $80–110 and the journey takes 7h.
- Website
- southwest.com
Flights from Harry Reid International Airport to San Diego International Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- $45–300
- Website
- alaskaair.com
Flights from Harry Reid International Airport to San Diego International Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- $95–300
- Website
- flyfrontier.com
Flights from Harry Reid International Airport to San Diego International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $80–260
- Website
- delta.com
Flights from Harry Reid International Airport to San Diego International Airport
- Ave. Duration
- 1h 17m
- When
- Every day
- Estimated price
- $45–300
- Phone
- +1 619-557-4555
- Website
- MTS
Tram from Civic Center Station to Iris Avenue Station
- Ave. Duration
- 36 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–14
- Website
- MTS
- Schedules at
- MTS Schedules
- Phone
- +1 833 766 3553
- Website
- Tufesa
Bus from Las Vegas to San Ysidro, CA
- Ave. Duration
- 7h
- Frequency
- Twice daily
- Estimated price
- $80–110
- Schedules at
- Tufesa
- Adult One way
- $80–110
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Las Vegas Strip to San Ysidro Bus Terminal
- Ave. Duration
- 9h 50m
- Frequency
- Twice daily
- Estimated price
- $65–120
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide








