There are 6 ways to get from Lawrence to Cape Girardeau by bus (Greyhound), train, bus, car, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Greyhound)
best- Take the bus from Lawrence Bus Stop to St Louis Bus Stationbus Greyhound US0180s
- Take the bus from St Louis Bus Station to Cape Girardeaubus Greyhound US1173
9h 34m$77–119Drive 385 mi
cheapest- Drive from Lawrence to Cape Girardeaucar 385 mi
6h 31m$71–102Train, bus
- Take the train from Lawrence Amtrak Station to Kansas Citytrain
- Take the train from Kansas City to St. Louistrain
- Take the bus from St Louis Bus Station to Cape Girardeaubus
11h 21m$197–312Bus, fly to Lambert–St. Louis International Airport
- Take the bus from Lawrence Bus Stop to Kansas City Bus Stationbus
- Fly from Kansas City (MCI) to Lambert–St. Louis International Airport (STL)plane MCI - STL
- Take the bus from St Louis Bus Station to Cape Girardeaubus
8h 20m$734–1,052Bus, fly to Williamson County Regional Airport, taxi
- Take the bus from Lawrence Bus Stop to Kansas City Bus Stationbus
- Fly from Kansas City (MCI) to Williamson County Regional Airport (MWA)plane MCI - MWA
- Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi
9h 13m$236–771Bus, fly to Barkley Regional Airport, taxi
- Take the bus from Lawrence Bus Stop to Kansas City Bus Stationbus
- Fly from Kansas City (MCI) to Barkley Regional Airport (PAH)plane MCI - PAH
- Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi
9h 7m$246–731
Kansas City (MCI) to Lambert–St. Louis International Airport (STL) flights
Comparing Your Travel Options
The cheapest way to get from Lawrence to Cape Girardeau is to drive which costs $70 - $110 and takes 6h 31m.
The fastest way to get from Lawrence to Cape Girardeau is to drive which takes 6h 31m and costs $70 - $110.
No, there is no direct bus from Lawrence to Cape Girardeau. However, there are services departing from Lawrence Bus Stop and arriving at Cape Girardeau via St Louis Bus Station. The journey, including transfers, takes approximately 9h 34m.
The distance between Lawrence and Cape Girardeau is 438 miles. The road distance is 387.3 miles.
The best way to get from Lawrence to Cape Girardeau without a car is to bus which takes 9h 34m and costs $75 - $120.
It takes approximately 9h 34m to get from Lawrence to Cape Girardeau, including transfers.
Lawrence to Cape Girardeau bus services, operated by Greyhound USA, depart from Lawrence Bus Stop station.
Lawrence to Cape Girardeau bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Yes, the driving distance between Lawrence to Cape Girardeau is 387 miles. It takes approximately 6h 31m to drive from Lawrence to Cape Girardeau.
Book your Lawrence to Cape Girardeau bus tickets online with Omio.
What companies run services between Lawrence, KS, USA and Cape Girardeau, MO, USA?
You can take a bus from Lawrence Bus Stop to Cape Girardeau via St Louis Bus Station and Cape Girardeau in around 9h 34m.
- Website
- southwest.com
Flights from Kansas City to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 3m
- When
- Every day
- Estimated price
- $80–550
- Website
- aa.com
Flights from Kansas City to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $100–600
- Website
- united.com
Flights from Kansas City to Barkley Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 6m
- When
- Every day
- Estimated price
- $100–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Lawrence Amtrak Station to Kansas City
- Ave. Duration
- 1h 32m
- Frequency
- Once daily
- Estimated price
- $22–35
- Website
- Amtrak
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $150–240
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Lawrence Bus Stop to St Louis Bus Station
- Ave. Duration
- 6h 25m
- Frequency
- Once daily
- Estimated price
- $50–85
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–29
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–29
- Website
- Greyhound
Bus from Lawrence Bus Stop to Kansas City Bus Station
- Ave. Duration
- 45 min
- Frequency
- 3 times a day
- Estimated price
- $6–11
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Once daily
- Estimated price
- $18–29
- Website
- Greyhound
Bus from Lawrence Bus Stop to Kansas City Bus Station
- Ave. Duration
- 45 min
- Frequency
- 3 times a day
- Estimated price
- $6–11
- Website
- Greyhound
Bus from Lawrence Bus Stop to Kansas City Bus Station
- Ave. Duration
- 45 min
- Frequency
- 3 times a day
- Estimated price
- $6–11
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Lawrence Bus Stop to Kansas City Bus Station
- Ave. Duration
- 45 min
- Frequency
- 6 times a week
- Estimated price
- $6–10
- Schedules at
- Flixbus USA
Bus from Lawrence Bus Stop to Kansas City Bus Station
- Ave. Duration
- 45 min
- Frequency
- 6 times a week
- Estimated price
- $6–10
- Schedules at
- Flixbus USA
Bus from Lawrence Bus Stop to Kansas City Bus Station
- Ave. Duration
- 45 min
- Frequency
- 6 times a week
- Estimated price
- $6–10
- Schedules at
- Flixbus USA
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Booking & Getting There
There are 25+ hotels available in Cape Girardeau.









