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How to get fromLewes to St. Louisby taxi, plane, bus (Greyhound), bus, train, car, or shuttle

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There are 6 ways to get from Lewes to St. Louis by taxi, plane, bus (Greyhound), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Salisbury–Ocean City–Wicomico Regional Airport, fly

    best
    1. Take the taxi from Lewes to Salisbury–Ocean City–Wicomico Regional Airport (SBY)taxi taxi
    2. Fly from Salisbury–Ocean City–Wicomico Regional Airport (SBY) to Lambert–St. Louis International Airport (STL)plane plane SBY - STL
    6h 58m
    $272–817

  2. Bus

    cheapest
    1. Take the bus from Lewes Transit Center to Wilmington Tcbus bus 305
    2. Take the bus from Wilmington Bus Station to Philadelphia Bus Stationbus bus
    3. Take the bus from Philadelphia Bus Station to St Louis Bus Stationbus bus
    26h 48m
    $141–288

  3. Bus, train via Washington

    1. Take the bus from Lewes Transit Center to Wilmington Tcbus bus 305
    2. Take the train from Wilmington to Washington Union Stationtrain train
    3. Take the train from Washington Union Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Louistrain train
    29h 38m
    $362–1,399

  4. Drive 905.3 mi

    1. Drive from Lewes to St. Louiscar car 905.3 mi
    16h 19m
    $166–239

  5. Shuttle to Philadelphia International Airport, fly

    1. Take a shuttle bus from Lewes Transit Center to Philadelphia Airportshuttle bus
    2. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    7h 15m
    $225–875

  6. Bus, train

    1. Take the bus from Lewes Transit Center to Wilmington Tcbus bus 305
    2. Take the train from Wilmington to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    36h 39m
    $427–899

Lewes to St. Louis by bus

Calendar12Weekly Buses
Duration26h 48mAverage Duration
Ticket$141Cheapest Price
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Questions & Answers

Map of how to get from Lewes to St. Louis.ExpandLaunch map view
  • Distance: 857.1 mi
  • Duration: 6h 58m

What companies run services between Lewes, DE, USA and St. Louis, MO, USA?

You can take a bus from Market St @ 2Nd St to St Louis Bus Station via Lewes Transit Center, Wilmington Tc, Wilmington Bus Station, and Philadelphia Bus Station in around 26h 48m.

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