There are 7 ways to get from Lewisburg to Knoxville by bus, plane, car, train, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Harrisburg International Airport, fly
best- Take the bus from Lewisburg to Harrisburg, Pabus
- Fly from Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS)plane MDT - TYS
7h 51m$194–811Drive 585.5 mi
cheapest- Drive from Lewisburg to Knoxvillecar 585.5 mi
10h 10m$107–155Bus
- Take the bus from Lewisburg to Port Authority Bus Terminalbus Fab10
- Take the bus from New York to Knoxvillebus Nyc
18h 57m$266–401Bus to Penn State University Park Airport, fly
- Take the bus from Williamsport to State Collegebus
- Fly from Penn State University Park Airport (SCE) to Mcghee Tyson Airport (TYS)plane SCE - TYS
7h 46m$205–825Bus, train to Philadelphia International Airport, fly
- Take the bus from Lewisburg to Harrisburg, Pabus
- Take the train from Harrisburg to 30th Street Stationtrain
- Fly from Philadelphia International Airport (PHL) to Mcghee Tyson Airport (TYS)plane PHL - TYS
8h 19m$266–1,127Bus, train
- Take the bus from Lewisburg to Harrisburg, Pabus 26
- Take the train from Harrisburg to Ny Moynihan Train Hall At Penn Stationtrain
- Take the bus from New York, NY to Knoxville, TNbus Ny
19h 46m$211–332Bus via Allentown
- Take the bus from Lewisburg to Allentownbus
- Take the bus from Allentown to New York City Chinatownbus
- Take the bus from New York, NY to Knoxville, TNbus Ny
23h 50m$156–216
Harrisburg International Airport (MDT) to Mcghee Tyson Airport (TYS) flights
Questions & Answers
The cheapest way to get from Lewisburg to Knoxville is to drive which costs $100 - $160 and takes 10h 10m.
The fastest way to get from Lewisburg to Knoxville is to bus and fly which takes 7h 46m and costs $200 - $850.
No, there is no direct bus from Lewisburg to Knoxville. However, there are services departing from Lewisburg and arriving at Knoxville via New York. The journey, including transfers, takes approximately 18h 57m.
The distance between Lewisburg and Knoxville is 589 miles. The road distance is 589 miles.
The best way to get from Lewisburg to Knoxville without a car is to bus which takes 18h 57m and costs $260 - $410.
It takes approximately 7h 51m to get from Lewisburg to Knoxville, including transfers.
Lewisburg to Knoxville bus services, operated by Fullington Trailways, depart from Lewisburg station.
Lewisburg to Knoxville bus services, operated by Fullington Trailways, arrive at Port Authority Bus Terminal station.
Yes, the driving distance between Lewisburg to Knoxville is 589 miles. It takes approximately 10h 10m to drive from Lewisburg to Knoxville.
There are 271+ hotels available in Knoxville.
What companies run services between Lewisburg, PA, USA and Knoxville, TN, USA?
You can take a bus from Lewisburg to Knoxville via Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 18h 57m.
- Website
- aa.com
Flights from Harrisburg International Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 4h 41m
- When
- Every day
- Estimated price
- $130–750
Flights from Harrisburg International Airport to Mcghee Tyson Airport via Philadelphia International Airport
- Ave. Duration
- 5h 24m
- When
- Every day
- Estimated price
- $130–750
Flights from Penn State University Park Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $130–750
Flights from Penn State University Park Airport to Mcghee Tyson Airport via Philadelphia International Airport
- Ave. Duration
- 5h 13m
- When
- Every day
- Estimated price
- $140–800
Flights from Philadelphia International Airport to Mcghee Tyson Airport
- Ave. Duration
- 2h 12m
- When
- Every day
- Estimated price
- $160–950
Flights from Philadelphia International Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $180–1,000
- Website
- united.com
Flights from Harrisburg International Airport to Mcghee Tyson Airport via Washington Dulles
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $120–700
Flights from Penn State University Park Airport to Mcghee Tyson Airport via Washington Dulles
- Ave. Duration
- 4h 34m
- When
- Every day
- Estimated price
- $120–700
Flights from Penn State University Park Airport to Mcghee Tyson Airport via Chicago O'Hare
- Ave. Duration
- 6h 28m
- When
- Every day
- Estimated price
- $180–900
Flights from Philadelphia International Airport to Mcghee Tyson Airport via Washington Dulles
- Ave. Duration
- 4h 13m
- When
- Monday to Saturday
- Estimated price
- $160–950
- Website
- delta.com
Flights from Harrisburg International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 57m
- When
- Every day
- Estimated price
- $150–800
Flights from Harrisburg International Airport to Mcghee Tyson Airport via Detroit
- Ave. Duration
- 5h 13m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $160–850
Flights from Philadelphia International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $210–1,100
Flights from Philadelphia International Airport to Mcghee Tyson Airport via Detroit
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $220–1,200
- Website
- allegiantair.com
Flights from Harrisburg International Airport to Mcghee Tyson Airport via Orlando Sanford
- Ave. Duration
- 7h 34m
- When
- Monday and Friday
- Estimated price
- $220–1,100
Flights from Philadelphia International Airport to Mcghee Tyson Airport
- Ave. Duration
- 2h
- When
- Monday and Friday
- Estimated price
- $160–950
- Website
- southwest.com
Flights from Philadelphia International Airport to Mcghee Tyson Airport via Nashville
- Ave. Duration
- 4h
- When
- Sunday
- Estimated price
- $210–1,100
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Harrisburg to 30th Street Station
- Ave. Duration
- 1h 44m
- Frequency
- Every 2 hours
- Estimated price
- $30–65
- Website
- Amtrak
Train from Harrisburg to Ny Moynihan Train Hall At Penn Station
- Ave. Duration
- 3h 29m
- Frequency
- Every 2 hours
- Estimated price
- $55–130
- Website
- Amtrak
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Lewisburg to Harrisburg, Pa
- Saver
- $18–40
- Flexible
- $38–40
Bus from Lewisburg to Harrisburg, Pa
- Saver
- $18–40
- Flexible
- $38–40
Bus from Lewisburg to Harrisburg, Pa
- Saver
- $18–40
- Flexible
- $38–40
- Phone
- +1 814-574-1827
- Website
- Fullington Tours
Bus from Lewisburg to Port Authority Bus Terminal
- Ave. Duration
- 5h 20m
- Frequency
- Once daily
- Estimated price
- $80–150
- Website
- Fullington Tours
Bus from Williamsport to State College
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $21–40
- Website
- Fullington Tours
Bus from Lewisburg to Allentown
- Ave. Duration
- 2h 50m
- Frequency
- Once daily
- Estimated price
- $35–70
- Website
- Fullington Tours
- Phone
- +1 646-630-7186
- [email protected]
- Website
- Wanda Coach
Bus from New York to Knoxville
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- $95–140
- Website
- Wanda Coach
- Book at
- GotoBus.com
- Adult One Way
- $95–140
- Phone
- +1 615-939-8887
- [email protected]
- Website
- New York to Tennessee Bus
Bus from New York, NY to Knoxville, TN
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- $95–110
- Website
- New York to Tennessee Bus
- Adult One-way
- $95–110
Bus from New York, NY to Knoxville, TN
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- $95–110
- Website
- New York to Tennessee Bus
- Adult One-way
- $95–110
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Allentown to New York City Chinatown
- Ave. Duration
- 3h
- Frequency
- 6 times a week
- Estimated price
- $20–35
- Schedules at
- Flixbus USA
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