There are 6 ways to get from Lewisburg to Louisville by bus, plane, bus (Flixbus), car, train, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Harrisburg International Airport, fly
best- Take the bus from Lewisburg to Harrisburg, Pabus
- Fly from Harrisburg International Airport (MDT) to Louisville International Airport (SDF)plane MDT - SDF
8h 46m$115–594Bus via Columbus
cheapest- Take the bus from Lewisburg to Harrisburg, Pabus 26
- Take the bus from Harrisburg Bus Station to Columbusbus
- Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus
17h$94–209Bus
- Take the bus from Lewisburg to Harrisburg, Pabus 26
- Take the bus from Harrisburg Bus Station to Cincinnatibus
- Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus
16h 57m$103–217Drive 575.4 mi
- Drive from Lewisburg to Louisvillecar 575.4 mi
10h 33m$105–152Bus to Penn State University Park Airport, fly
- Take the bus from Williamsport to State Collegebus
- Fly from Penn State University Park Airport (SCE) to Louisville International Airport (SDF)plane SCE - SDF
8h 48m$126–608Bus, train to Philadelphia International Airport, fly
- Take the bus from Lewisburg to Harrisburg, Pabus
- Take the train from Harrisburg to 30th Street Stationtrain
- Fly from Philadelphia International Airport (PHL) to Louisville International Airport (SDF)plane PHL - SDF
9h 31m$182–865
Lewisburg to Louisville by bus and foot
Questions & Answers
The cheapest way to get from Lewisburg to Louisville is to drive which costs $100 - $160 and takes 10h 33m.
The fastest way to get from Lewisburg to Louisville is to bus and fly which takes 8h 46m and costs $110 - $600.
No, there is no direct bus from Lewisburg to Louisville station. However, there are services departing from Lewisburg and arriving at Louisville, KY Bus Station via Harrisburg Bus Station, Vine St & Martin Luther King Dr and Cincinnati - Downtown. The journey, including transfers, takes approximately 16h 57m.
The distance between Lewisburg and Louisville is 586 miles. The road distance is 578.8 miles.
The best way to get from Lewisburg to Louisville without a car is to bus which takes 16h 57m and costs $100 - $220.
It takes approximately 8h 46m to get from Lewisburg to Louisville, including transfers.
Lewisburg to Louisville bus services, operated by Trailways, depart from Lewisburg station.
Lewisburg to Louisville bus services, operated by Trailways, arrive at Harrisburg, Pa station.
Yes, the driving distance between Lewisburg to Louisville is 579 miles. It takes approximately 10h 33m to drive from Lewisburg to Louisville.
There are 507+ hotels available in Louisville.
What companies run services between Lewisburg, PA, USA and Louisville, KY, USA?
You can take a bus from Lewisburg to Louisville, KY Bus Station via Harrisburg Bus Station, Cincinnati, Vine St & Martin Luther King Dr, Race St & Court St, and Cincinnati - Downtown in around 16h 57m.
- Website
- united.com
Flights from Harrisburg International Airport to Louisville International Airport via Washington Dulles
- Ave. Duration
- 4h 2m
- When
- Every day
- Estimated price
- $95–550
Flights from Harrisburg International Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 5h 55m
- When
- Every day
- Estimated price
- $120–650
Flights from Penn State University Park Airport to Louisville International Airport via Washington Dulles
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $95–550
Flights from Penn State University Park Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 5h 48m
- When
- Every day
- Estimated price
- $120–650
Flights from Philadelphia International Airport to Louisville International Airport via Washington Dulles
- Ave. Duration
- 4h 3m
- When
- Every day
- Estimated price
- $130–750
- Website
- aa.com
Flights from Harrisburg International Airport to Louisville International Airport via Charlotte
- Ave. Duration
- 5h 2m
- When
- Every day
- Estimated price
- $110–600
Flights from Harrisburg International Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 5h 10m
- When
- Saturday
- Estimated price
- $120–650
Flights from Harrisburg International Airport to Louisville International Airport via Philadelphia International Airport
- Ave. Duration
- 6h 42m
- When
- Every day
- Estimated price
- $100–600
Flights from Penn State University Park Airport to Louisville International Airport via Charlotte
- Ave. Duration
- 4h 38m
- When
- Every day
- Estimated price
- $110–600
Flights from Penn State University Park Airport to Louisville International Airport via Philadelphia International Airport
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $110–600
Flights from Philadelphia International Airport to Louisville International Airport
- Ave. Duration
- 2h 18m
- When
- Every day
- Estimated price
- $130–750
- Website
- delta.com
Flights from Harrisburg International Airport to Louisville International Airport via Detroit
- Ave. Duration
- 5h 18m
- When
- Every day
- Estimated price
- $100–600
Flights from Harrisburg International Airport to Louisville International Airport via Atlanta
- Ave. Duration
- 4h 57m
- When
- Every day
- Estimated price
- $130–700
Flights from Philadelphia International Airport to Louisville International Airport via Detroit
- Ave. Duration
- 4h 16m
- When
- Every day
- Estimated price
- $150–850
- Website
- southwest.com
Flights from Philadelphia International Airport to Louisville International Airport via Nashville
- Ave. Duration
- 4h 30m
- When
- Saturday, Sunday, Tuesday, and Wednesday
- Estimated price
- $160–850
Flights from Philadelphia International Airport to Louisville International Airport via Chicago Midway
- Ave. Duration
- 4h 52m
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $180–900
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Harrisburg to 30th Street Station
- Ave. Duration
- 1h 44m
- Frequency
- Every 2 hours
- Estimated price
- $30–70
- Website
- Amtrak
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Lewisburg to Harrisburg, Pa
- Saver
- $18–40
- Flexible
- $38–40
Bus from Lewisburg to Harrisburg, Pa
- Saver
- $18–40
- Flexible
- $38–40
Bus from Lewisburg to Harrisburg, Pa
- Saver
- $18–40
- Flexible
- $38–40
Bus from Lewisburg to Harrisburg, Pa
- Saver
- $18–40
- Flexible
- $38–40
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Harrisburg Bus Station to Cincinnati
- Ave. Duration
- 10h 50m
- Frequency
- 4 times a week
- Estimated price
- $75–130
- Schedules at
- Flixbus USA
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Cincinnati - Downtown to Louisville, KY Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $9–45
- Website
- Barons Bus
Bus from Columbus - Downtown - Mound St to Louisville, KY Bus Station
- Ave. Duration
- 4h 35m
- Frequency
- Twice daily
- Estimated price
- $21–60
- Website
- Barons Bus
- Phone
- +1 814-574-1827
- Website
- Fullington Tours
Bus from Williamsport to State College
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $21–40
- Website
- Fullington Tours
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Harrisburg Bus Station to Columbus
- Ave. Duration
- 8h 45m
- Frequency
- Twice daily
- Estimated price
- $55–110
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide














