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How to get fromLexington to Chicagoby bus, plane, train (Amtrak), car, train, or bus (Flixbus)

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There are 9 ways to get from Lexington to Chicago by bus, plane, train (Amtrak), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, line 3 bus to Piedmont Triad International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from Lexington to High Point Terminalbus bus
    2. Take the bus from High Point Terminal to Motel 6bus bus
    3. Fly from Piedmont Triad International Airport (GSO) to Chicago O'Hare International Airport (ORD)plane plane GSO - ORD
    5h 34m
    $101–435

  2. Bus

    cheapest
    1. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus - Mound St to Chicagobus bus Columbus / ...
    19h 29m
    $68–176

  3. Train (Amtrak)

    1. Take the train from High Point to Carytrain train Piedmont / ...
    2. Take the train from Cary to Chicago Union Stationtrain train Floridian
    29h 23m
    $371–815

  4. Drive 708.8 mi

    1. Drive from Lexington to Chicagocar car 708.8 mi
    12h 33m
    $130–187

  5. Train to Raleigh-Durham International Airport, fly to Chicago Midway International Airport

    1. Take the train from High Point to Durham Amtrak Stationtrain train
    2. Fly from Raleigh-Durham International Airport (RDU) to Chicago Midway International Airport (MDW)plane plane RDU - MDW
    7h 44m
    $181–366

  6. Train to Charlotte Douglas International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from High Point to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Chicago O'Hare International Airport (ORD)plane plane CLT - ORD
    7h 54m
    $155–481

  7. Train to Charlotte Douglas International Airport, fly to Chicago Midway International Airport

    1. Take the train from High Point to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Chicago Midway International Airport (MDW)plane plane CLT - MDW
    7h 32m
    $115–511

  8. Train to Raleigh-Durham International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from High Point to Durham Amtrak Stationtrain train
    2. Fly from Raleigh-Durham International Airport (RDU) to Chicago O'Hare International Airport (ORD)plane plane RDU - ORD
    8h 22m
    $201–816

  9. Bus via Columbus

    1. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus to Chicago Bus Stationbus bus FlixBus 2511 / ...
    19h 53m
    $95–199

Lexington to Chicago by bus

Calendar7Weekly Buses
Duration19h 29mAverage Duration
Ticket$68Cheapest Price
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Questions & Answers

Map of how to get from Lexington to Chicago.ExpandLaunch map view
  • Distance: 639.2 mi
  • Duration: 5h 34m

What companies run services between Lexington, NC, USA and Chicago, IL, USA?

You can take a bus from Lexington to Chicago via Winston Salem(Trans Center) and Columbus - Mound St in around 19h 29m. Alternatively, you can take a bus from Lexington to Chicago Union Station via High Point Terminal, High Point, and Cary in around 29h 23m.

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