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How to get fromLexington to Knoxvilleby plane, bus, shuttle, car, or train

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There are 5 ways to get from Lexington to Knoxville by plane, bus, shuttle, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Piedmont Triad International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS)plane plane GSO - TYS
    6h 14m
    $188–900

  2. Drive 248.8 mi

    cheapest
    1. Drive from Lexington to Knoxvillecar car 248.8 mi
    4h 46m
    $46–66

  3. Bus, shuttle, drive

    1. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    2. Take a shuttle bus from Asheville Airport to Black Bear Resortshuttle bus
    3. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    4. Drive from Hot Springs to Chilhowee at Holstoncar car
    11h 33m
    $377–421

  4. Train to Charlotte Douglas International Airport, fly

    1. Take the train from High Point to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    6h 26m
    $181–831

  5. Bus, shuttle, drive via Charlotte Airport (CLT)

    1. Take the bus from Winston Salem(Trans Center) to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    11h 38m
    $369–420

Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS) flights

Calendar110Weekly Planes
Duration4h 40mAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

Map of how to get from Lexington to Knoxville.ExpandLaunch map view
  • Distance: 272.9 mi
  • Duration: 6h 14m

What companies run services between Lexington, NC, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Piedmont Triad International Airport (GSO) to Mcghee Tyson Airport (TYS) hourly.

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