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How to get fromLexington to Louisvilleby plane, bus (Greyhound), car, or train

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There are 7 ways to get from Lexington to Louisville by plane, bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Piedmont Triad International Airport to Louisville International Airport

    best
    1. Fly from Piedmont Triad International Airport (GSO) to Louisville International Airport (SDF)plane plane GSO - SDF
    7h 16m
    $135–682

  2. Bus

    cheapest
    1. Take the bus from Lexington Davidson Co Trans Term to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    17h 5m
    $62–158

  3. Bus via Charleston

    1. Take the bus from Lexington Davidson Co Trans Term to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Charleston, WVbus bus
    3. Take the bus from Charleston Bus Station to Wilson & Ferrell Shell Station - Columbusbus bus
    4. Take the bus from N Wilson Rd & Ferrell Pl - Columbus to Louisville, KY Bus Stationbus bus
    16h 25m
    $74–183

  4. Drive 441.6 mi

    1. Drive from Lexington to Louisvillecar car 441.6 mi
    8h 31m
    $81–117

  5. Train to Charlotte Douglas International Airport, fly to Louisville International Airport

    1. Take the train from High Point to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Louisville International Airport (SDF)plane plane CLT - SDF
    7h 34m
    $124–668

  6. Train to Raleigh-Durham International Airport, fly to Louisville International Airport

    1. Take the train from High Point to Durham Amtrak Stationtrain train
    2. Fly from Raleigh-Durham International Airport (RDU) to Louisville International Airport (SDF)plane plane RDU - SDF
    8h
    $124–613

  7. Train to Charlotte Douglas International Airport, fly to Blue Grass Airport, drive

    1. Take the train from High Point to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Blue Grass Airport (LEX)plane plane CLT - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    7h 44m
    $166–884

Lexington to Louisville by bus

Calendar7Weekly Buses
Duration16h 25mAverage Duration
Ticket$74Cheapest Price
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Questions & Answers

Map of how to get from Lexington to Louisville.ExpandLaunch map view
  • Distance: 389 mi
  • Duration: 7h 16m

What companies run services between Lexington, NC, USA and Louisville, KY, USA?

American Airlines, Delta, and two other airlines fly from Piedmont Triad International Airport (GSO) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Lexington Davidson Co Trans Term to Louisville, KY Bus Station via Winston Salem(Trans Center), Charleston Bus Station, and N Wilson Rd & Ferrell Pl - Columbus in around 16h 25m.

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