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How to get fromLexington to Des Moinesby bus (Greyhound), car, bus, or plane

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There are 6 ways to get from Lexington to Des Moines by bus (Greyhound), car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Lexington to Des Moinesbus bus Greyhound US0123S
    7h 38m
    $79–144

  2. Drive 352.3 mi

    cheapest
    1. Drive from Lexington to Des Moinescar car 352.3 mi
    5h 34m
    $65–93

  3. Bus to Kearney Municipal Airport, fly

    1. Take the bus from Lexington to Kearneybus bus
    2. Fly from Kearney Municipal Airport (EAR) to Des Moines (DSM)plane plane EAR - DSM
    6h 44m
    $226–861

  4. Bus to North Platte Regional Airport Lee Bird Field, fly

    1. Take the bus from Lexington to North Plattebus bus
    2. Fly from North Platte Regional Airport Lee Bird Field (LBF) to Des Moines (DSM)plane plane LBF - DSM
    6h 47m
    $214–812

  5. Bus to Central Nebraska Regional Airport, fly

    1. Take the bus from Lexington to Grand Island Bus Stationbus bus
    2. Fly from Central Nebraska Regional Airport (GRI) to Des Moines (DSM)plane plane GRI - DSM
    7h 56m
    $284–982

  6. Drive to Mccook Ben Nelson Regional Airport, fly

    1. Drive from Lexington to Mccook Ben Nelson Regional Airport (MCK)car car
    2. Fly from Mccook Ben Nelson Regional Airport (MCK) to Des Moines (DSM)plane plane MCK - DSM
    5h 44m
    $161–741

Kearney Municipal Airport (EAR) to Des Moines (DSM) flights

Calendar11Weekly Planes
Duration4h 54mAverage Duration
Ticket$147Cheapest Price
See schedules

Questions & Answers

Map of how to get from Lexington to Des Moines.ExpandLaunch map view
  • Distance: 364.2 mi
  • Duration: 7h 38m

What companies run services between Lexington, NE, USA and Des Moines, IA, USA?

Greyhound USA operates a bus from Lexington to Des Moines twice daily. Tickets cost $50–110 and the journey takes 7h 35m.

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