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How to get fromLexington to Chicagoby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Lexington to Chicago by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Columbia to Chicago O'Hare International Airport

    best
    1. Fly from Columbia (CAE) to Chicago O'Hare International Airport (ORD)plane plane CAE - ORD
    3h 28m
    $80–339

  2. Drive to Greenville–Spartanburg International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Lexington to Greenville–Spartanburg International Airport (GSP)car car
    2. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)plane plane GSP - ORD
    4h 51m
    $75–351

  3. Bus via Columbus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Columbusbus bus
    4. Take the bus from Columbus to Chicagobus bus
    23h 57m
    $150–282

  4. Bus, train

    1. Take the bus from Columbia, SC to Raleigh, NCbus bus Augusta
    2. Take the train from Cary to Chicago Union Stationtrain train Floridian
    30h 41m
    $636–1,066

  5. Drive  760.3 mi

    1. Drive from Lexington to Chicagocar car 760.3 mi
    14h 11m
    $139–201

  6. Fly Columbia to Chicago Midway International Airport

    1. Fly from Columbia (CAE) to Chicago Midway International Airport (MDW)plane plane CAE - MDW
    4h 58m
    $95–419

  7. Drive to Charleston International Airport, fly to Chicago Midway International Airport

    1. Drive from Lexington to Charleston-Airport-CHScar car
    2. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    4h 47m
    $107–494

  8. Bus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    24h 7m
    $203–337

Columbia (CAE) to Chicago O'Hare International Airport (ORD) flights

Calendar94Weekly Planes
Duration4h 2mAverage Duration
Ticket$54Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Chicago.ExpandLaunch map view
  • Distance: 692.4 mi
  • Duration: 3h 28m

What companies run services between Lexington, SC, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Columbia (CAE) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a vehicle from Lexington to Chicago via Columbia, SC, Camden, Charlotte, and Columbus in around 23h 57m.

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