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How to get fromLexington to Florida Keysby plane, bus (Greyhound, Flixbus), bus, train, or car

Find Transport to Florida Keys

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There are 5 ways to get from Lexington to Florida Keys by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia

    best
    1. Fly from Columbia (CAE) to Key West International Airport (EYW)plane plane CAE - EYW
    7h 5m
    $245–878
  2. Drive 759.9 mi

    cheapest
    1. Drive from Lexington to Florida Keyscar car 759.9 mi
    14h 13m
    $139–201
  3. Bus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Savannah Bus Stationbus bus
    3. Take the bus from Savannah Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    25h 30m
    $194–330
  4. Bus, train

    1. Take the bus from Laurel Sumter East to James E Clyburn Intermodal Transportation Centerbus bus 44
    2. Take the bus from Sumter Bus Stop to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h 9m
    $303–581
  5. Bus to Augusta Regional Airport At Bush Field, fly

    1. Take the bus from Columbia, SC to Augustabus bus
    2. Fly from Augusta Regional Airport At Bush Field (AGS) to Key West International Airport (EYW)plane plane AGS - EYW
    10h 8m
    $237–551

Columbia (CAE) to Key West International Airport (EYW) flights

Calendar50Weekly Planes
Duration5h 22mAverage Duration
Ticket$145Cheapest Price
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Questions & Answers

What companies run services between Lexington, SC, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Columbia (CAE) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Lexington to Florida Keys via Columbia, SC, Camden, Savannah Bus Station, Ft Lauderdale Broward Park & Ride, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 25h 30m.

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Train operators
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