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How to get fromLexington to Florida Keysby plane, bus (Greyhound, Flixbus), bus, train, shuttle, or car

Find Transport to Florida Keys

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There are 5 ways to get from Lexington to Florida Keys by plane, bus (Greyhound, Flixbus), bus, train, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Columbia (CAE) to Key West International Airport (EYW)plane plane CAE - EYW
    7h 14m
    $160–458

  2. Drive  759.9 mi

    cheapest
    1. Drive from Lexington to Florida Keyscar car 759.9 mi
    14h 13m
    $139–201

  3. Bus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    27h 17m
    $231–336

  4. Bus, train, shuttle

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to West Palm Beach Amtrak Stationtrain train
    4. Take the bus from West Palm Beach, FL to Fort Lauderdale Airportbus bus
    5. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    29h 13m
    $611–913

  5. Bus, train

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    29h 39m
    $475–737

Columbia (CAE) to Key West International Airport (EYW) flights

Calendar47Weekly Planes
Duration5h 45mAverage Duration
Ticket$59Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Florida Keys.ExpandLaunch map view
  • Distance: 679.8 mi
  • Duration: 7h 14m

What companies run services between Lexington, SC, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Columbia (CAE) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Lexington to Florida Keys via Columbia, SC, Camden, Fayetteville Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 27h 17m.

Airlines
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