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How to get fromLexington to Indianapolisby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

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There are 5 ways to get from Lexington to Indianapolis by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Columbia (CAE) to Indianapolis (IND)plane plane CAE - IND
    4h 52m
    $120–586
  2. Drive  580.8 mi

    cheapest
    1. Drive from Lexington to Indianapoliscar car 580.8 mi
    11h
    $96–139
  3. Bus via Atlanta

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Indianapolisbus bus
    19h 47m
    $198–292
  4. Bus, train

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the train from Charlotte Amtrak Station to Charlottesvilletrain train
    4. Take the train from Charlottesville to Indianapolistrain train
    26h 27m
    $558–897
  5. Bus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Columbusbus bus
    4. Take the bus from Columbus to Cincinnatibus bus
    5. Take the bus from Cincinnati to Indianapolisbus bus
    22h 7m
    $144–298

Columbia (CAE) to Indianapolis (IND) flights

Calendar139Weekly Planes
Duration5h 1mAverage Duration
Ticket$90Cheapest Price
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Comparing Your Travel Options

What companies run services between Lexington, SC, USA and Indianapolis, IN, USA?

Delta, American Airlines, and United Airlines fly from Columbia (CAE) to Indianapolis (IND) hourly. Alternatively, you can take a vehicle from Lexington to Indianapolis via Columbia, SC, Camden, and Atlanta Bus Station in around 19h 47m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There