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How to get fromLexington to Key Westby plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

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There are 6 ways to get from Lexington to Key West by plane, bus (Greyhound, Flixbus), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia

    best
    1. Fly from Columbia (CAE) to Key West International Airport (EYW)plane plane CAE - EYW
    4h 18m
    $179–797

  2. Drive to Greenville–Spartanburg International Airport, fly

    cheapest
    1. Drive from Lexington to Greenville–Spartanburg International Airport (GSP)car car
    2. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    5h 55m
    $109–439

  3. Bus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Savannah Bus Stationbus bus
    3. Take the bus from Savannah Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Ft Lauderdale Broward Park & Ride to Miami Airport Stationbus bus
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    6. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    26h 16m
    $209–345

  4. Bus, train

    1. Take the bus from Laurel Sumter East to James E Clyburn Intermodal Transportation Centerbus bus 44
    2. Take the bus from Sumter Bus Stop to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    28h 56m
    $318–596

  5. Drive 775.3 mi

    1. Drive from Lexington to Key Westcar car 775.3 mi
    14h 36m
    $142–205

  6. Bus, shuttle

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Savannah Bus Stationbus bus
    3. Take the bus from Savannah Bus Station to Ft Lauderdale Broward Park & Ridebus bus
    4. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Miami International Airportbus bus
    5. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    26h 53m
    $367–521

Columbia (CAE) to Key West International Airport (EYW) flights

Calendar50Weekly Planes
Duration5h 22mAverage Duration
Ticket$145Cheapest Price
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Questions & Answers

Map of how to get from Lexington to Key West.ExpandLaunch map view
  • Distance: 660.6 mi
  • Duration: 4h 18m

What companies run services between Lexington, SC, USA and Key West, FL, USA?

Delta and American Airlines fly from Columbia (CAE) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Lexington to N Roosevelt & 3rd Street via Columbia, SC, Camden, Savannah Bus Station, Ft Lauderdale Broward Park & Ride, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 26h 16m.

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