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How to get fromLexington to Key Westby plane, bus (Greyhound, Flixbus), bus, train, or car

Find Transport to Key West

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There are 5 ways to get from Lexington to Key West by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia

    best
    1. Fly from Columbia (CAE) to Key West International Airport (EYW)plane plane CAE - EYW
    4h 49m
    $94–367

  2. Bus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    28h 3m
    $215–336

  3. Bus, train

    1. Take the bus from Laurel Sumter East to James E Clyburn Intermodal Transportation Centerbus bus 44
    2. Take the bus from Sumter Bus Stop to Charleston Bus Stationbus bus
    3. Take the train from Charleston Amtrak Station to Hollywood Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    28h 56m
    $252–506

  4. Drive  775.3 mi

    1. Drive from Lexington to Key Westcar car 775.3 mi
    14h 36m
    $142–205

  5. Drive to Greenville–Spartanburg International Airport, fly

    1. Drive from Lexington to Greenville–Spartanburg International Airport (GSP)car car
    2. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    5h 49m
    $99–409

Columbia (CAE) to Key West International Airport (EYW) flights

Calendar77Weekly Planes
Duration5h 47mAverage Duration
Ticket$59Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Key West.ExpandLaunch map view
  • Distance: 660.6 mi
  • Duration: 4h 49m

What companies run services between Lexington, SC, USA and Key West, FL, USA?

American Airlines and Delta fly from Columbia (CAE) to Key West International Airport (EYW) every 2 hours. Alternatively, you can take a vehicle from Lexington to N Roosevelt & 3rd Street via Columbia, SC, Camden, Fayetteville Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 28h 3m.

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