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How to get fromLexington to Panama City Beachby plane, bus (Greyhound), or car

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There are 5 ways to get from Lexington to Panama City Beach by plane, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Northwest Florida Beaches International Airport

    best
    1. Fly from Columbia (CAE) to Northwest Florida Beaches International Airport (ECP)plane plane CAE - ECP
    4h 18m
    $208–899

  2. Drive 418.6 mi

    cheapest
    1. Drive from Lexington to Panama City Beachcar car 418.6 mi
    8h 51m
    $77–111

  3. Bus via Tallahassee

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    16h 51m
    $162–274

  4. Fly to Destin–Fort Walton Beach Airport, drive

    1. Fly from Columbia (CAE) to Destin–Fort Walton Beach Airport (VPS)plane plane CAE - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 21m
    $168–850

  5. Bus

    1. Take the bus from Columbia, SC to Camdenbus bus
    2. Take the bus from Camden to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Panama City Beach Bus Stationbus bus
    17h 31m
    $162–274

Columbia (CAE) to Northwest Florida Beaches International Airport (ECP) flights

Calendar82Weekly Planes
Duration5hAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

Map of how to get from Lexington to Panama City Beach.ExpandLaunch map view
  • Distance: 396.4 mi
  • Duration: 4h 18m

What companies run services between Lexington, SC, USA and Panama City Beach, FL, USA?

Delta, American Airlines, and United Airlines fly from Columbia (CAE) to Northwest Florida Beaches International Airport (ECP) every 2 hours. Alternatively, you can take a vehicle from Lexington to Panama City Beach via Columbia, SC, Camden, Jacksonville, Tallahassee, and Panama City Beach Bus Station in around 16h 51m.

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