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How to get fromLexington to Cape Girardeauby car, bus, plane, taxi, or train

Find Transport to Cape Girardeau

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There are 6 ways to get from Lexington to Cape Girardeau by car, bus, plane, taxi, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus

    best
    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    13h 40m
    $107–247

  2. Drive  325.1 mi

    cheapest
    1. Drive from Lexington to Cape Girardeaucar car 325.1 mi
    5h 48m
    $58–83

  3. Fly Blue Grass Airport to Williamson County Regional Airport, taxi

    1. Fly from Blue Grass Airport (LEX) to Williamson County Regional Airport (MWA)plane plane LEX - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    9h 38m
    $197–522

  4. Drive, bus, train, taxi

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Champaign Intermodal Trans Ctrbus bus
    4. Take the train from Champaign-Urbana to Carbondaletrain train
    5. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    14h 17m
    $253–393

  5. Fly Blue Grass Airport to Barkley Regional Airport, taxi

    1. Fly from Blue Grass Airport (LEX) to Barkley Regional Airport (PAH)plane plane LEX - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    10h 8m
    $212–562

  6. Drive to Covington, fly to Cape Girardeau Municipal Airport

    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Cape Girardeau Municipal Airport (CGI)plane plane CVG - CGI
    6h 40m
    $227–949

Blue Grass Airport (LEX) to Williamson County Regional Airport (MWA) flights

Calendar24Weekly Planes
Duration6h 14mAverage Duration
Ticket$65Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Cape Girardeau.ExpandLaunch map view
  • Distance: 486.7 mi
  • Duration: 13h 40m

What companies run services between Lexington, KY, USA and Cape Girardeau, MO, USA?

There is no direct connection from Lexington to Cape Girardeau. However, you can drive to Middletown Station @ Target, take the line 31 bus to S 5th @ W Jefferson, walk to W Jefferson @ S 6th, take the line 10 bus to W Broadway @ S 10th, walk to Louisville, KY, take the bus to Evansville, IN, take the bus to St Louis Bus Station, take the bus to Cape Girardeau, then take the taxi to Cape Girardeau. Alternatively, you can drive from Lexington to Cape Girardeau in around 5h 48m.

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