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How to get fromLexington to Florenceby plane, bus (Greyhound), car, or bus

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There are 5 ways to get from Lexington to Florence by plane, bus (Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Blue Grass Airport (LEX) to Florence Regional Airport (FLO)plane plane LEX - FLO
    6h 48m
    $87–475
  2. Bus

    1. Take the bus from Lexington Bus Stop to Atlanta Bus Stationbus bus Greyhound US0110
    2. Take the bus from Atlanta to Florencebus bus Ses 987 / ...
    16h 48m
    $106–211
  3. Drive 481.9 mi

    1. Drive from Lexington to Florencecar car 481.9 mi
    9h 10m
    $88–127
  4. Fly to Myrtle Beach, bus

    1. Fly from Blue Grass Airport (LEX) to Myrtle Beach (MYR)plane plane LEX - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    9h 32m
  5. Bus via Sumter

    1. Take the bus from Lexington Bus Stop to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Sumterbus bus
    3. Take the bus from Sumter Bus Stop to Florence Bus Stationbus bus
    18h 26m

Lexington to Florence by bus

Calendar14Weekly Buses
Duration16h 48mAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

What companies run services between Lexington, KY, USA and Florence, SC, USA?

American Airlines flies from Blue Grass Airport (LEX) to Florence Regional Airport (FLO) 3 times a day. Alternatively, you can take a bus from Tates Creek @ Dove Run to Florence via Transit Center, Walmart @ Northpark, Lexington Bus Stop, and Atlanta in around 16h 48m.

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