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How to get fromLexington to Florenceby plane, car, bus, or train

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There are 5 ways to get from Lexington to Florence by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Blue Grass Airport to Florence Regional Airport

    best
    1. Fly from Blue Grass Airport (LEX) to Florence Regional Airport (FLO)plane plane LEX - FLO
    6h 39m
    $67–355

  2. Drive, bus

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Nashvillebus bus
    3. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    19h 36m
    $133–227

  3. Drive  481.9 mi

    1. Drive from Lexington to Florencecar car 481.9 mi
    9h 10m
    $83–119

  4. Fly Blue Grass Airport to Myrtle Beach, bus

    1. Fly from Blue Grass Airport (LEX) to Myrtle Beach (MYR)plane plane LEX - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    9h 28m
    $70–325

  5. Drive to Covington, fly to Charleston International Airport, train

    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Charleston International Airport (CHS)plane plane CVG - CHS
    3. Take the train from Charleston Amtrak Station to Florence Stationtrain train
    7h 54m
    $188–854

Blue Grass Airport (LEX) to Florence Regional Airport (FLO) flights

Calendar21Weekly Planes
Duration4h 45mAverage Duration
Ticket$54Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Florence.ExpandLaunch map view
  • Distance: 397.5 mi
  • Duration: 6h 39m

What companies run services between Lexington, KY, USA and Florence, SC, USA?

American Airlines flies from Blue Grass Airport (LEX) to Florence Regional Airport (FLO) 3 times a day.

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