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How to get fromLexington to Hannibalby car, bus, shuttle, train, plane, or taxi

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There are 11 ways to get from Lexington to Hannibal by car, bus, shuttle, train, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus, shuttle

    best
    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    4. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    14h 36m
    $95–219

  2. Fly Blue Grass Airport to Burlington Municipal Airport, drive

    cheapest
    1. Fly from Blue Grass Airport (LEX) to Burlington Municipal Airport (BRL)plane plane LEX - BRL
    2. Drive from Burlington Municipal Airport (BRL) to Hannibalcar car
    10h 54m
    $78–387

  3. Drive, bus, train via Chicago (Amtrak)

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Lafayette Amtrak Stationbus bus
    3. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train
    17h 53m
    $329–523

  4. Drive  452.7 mi

    1. Drive from Lexington to Hannibalcar car 452.7 mi
    7h 52m
    $83–120

  5. Fly Blue Grass Airport to Columbia Regional Airport, shuttle

    1. Fly from Blue Grass Airport (LEX) to Columbia Regional Airport (COU)plane plane LEX - COU
    2. Take a shuttle bus from Columbia to Hannibalshuttle bus
    10h 17m
    $132–476

  6. Drive, bus, train

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Galesburgbus bus
    4. Take the train from Galesburg Amtrak Station to Quincy Amtrak Stationtrain train
    15h 4m
    $216–348

  7. Drive, bus, train #2 (Amtrak)

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    3. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train
    15h 42m
    $284–423

  8. Fly Blue Grass Airport to Lambert–St. Louis International Airport, shuttle

    1. Fly from Blue Grass Airport (LEX) to Lambert–St. Louis International Airport (STL)plane plane LEX - STL
    2. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    10h 20m
    $105–575

  9. Drive to Louisville International Airport, fly to Quincy Regional Airport, taxi

    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Quincy Regional Airport (UIN)plane plane SDF - UIN
    3. Take the taxi from Quincy Regional Airport (UIN) to Hannibaltaxi taxi
    6h 15m
    $164–551

  10. Fly Blue Grass Airport to Quincy Regional Airport, taxi

    1. Fly from Blue Grass Airport (LEX) to Quincy Regional Airport (UIN)plane plane LEX - UIN
    2. Take the taxi from Quincy Regional Airport (UIN) to Hannibaltaxi taxi
    9h 8m
    $137–462

  11. Drive, bus to Nashville, fly to Quincy Regional Airport, taxi

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Nashvillebus bus
    3. Fly from Nashville (BNA) to Quincy Regional Airport (UIN)plane plane BNA - UIN
    4. Take the taxi from Quincy Regional Airport (UIN) to Hannibaltaxi taxi
    10h 20m
    $271–715

Blue Grass Airport (LEX) to Columbia Regional Airport (COU) flights

Calendar46Weekly Planes
Duration5h 47mAverage Duration
Ticket$69Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Hannibal.ExpandLaunch map view
  • Distance: 493 mi
  • Duration: 14h 36m

What companies run services between Lexington, KY, USA and Hannibal, MO, USA?

There is no direct connection from Lexington to Hannibal. However, you can drive to Middletown Station @ Target, take the line 31 bus to S 5th @ W Jefferson, walk to W Jefferson @ S 6th, take the line 10 bus to W Broadway @ S 10th, walk to Louisville, KY, take the bus to Evansville, IN, take the bus to St Louis Bus Station, walk to Civic Center Transit Center, take the line 4 bus to North Hanley Transit Center, walk to St. Louis, take the shuttle to Hannibal, then take the taxi to Hannibal. Alternatively, you can take a vehicle from Lexington to Hannibal via Middletown Station @ Target, S 5th @ W Jefferson, S Roy Wilkins @ W Muhammad Ali, W Broadway @ S 10th, Louisville, KY, Lafayette Amtrak Station, Lafayette Amtrak Station, Chicago Union Station, and Quincy Amtrak Station in around 17h 53m.

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