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How to get fromLexington to Hannibalby car, bus, shuttle, train, or plane

Find Transport to Hannibal

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There are 6 ways to get from Lexington to Hannibal by car, bus, shuttle, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus, shuttle

    best
    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    4. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    14h 2m
    $93–221

  2. Drive  452.7 mi

    cheapest
    1. Drive from Lexington to Hannibalcar car 452.7 mi
    7h 52m
    $83–120

  3. Drive, bus, train via Chicago (Amtrak)

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Lafayette Amtrak Stationbus bus
    3. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train
    17h 53m
    $208–408

  4. Fly, shuttle

    1. Fly from Blue Grass Airport (LEX) to Columbia Regional Airport (COU)plane plane LEX - COU
    2. Take a shuttle bus from Columbia to Hannibalshuttle bus
    11h 13m
    $132–476

  5. Drive, bus, train

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Galesburgbus bus
    4. Take the train from Galesburg Amtrak Station to Quincy Amtrak Stationtrain train
    14h 40m
    $171–298

  6. Drive, bus, train #2

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train
    15h 52m
    $189–358

Blue Grass Airport (LEX) to Columbia Regional Airport (COU) flights

Calendar56Weekly Planes
Duration5h 49mAverage Duration
Ticket$69Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Hannibal.ExpandLaunch map view
  • Distance: 492.2 mi
  • Duration: 14h 2m

What companies run services between Lexington, KY, USA and Hannibal, MO, USA?

There is no direct connection from Lexington to Hannibal. However, you can drive to Middletown Station @ Target, take the line 31 bus to S 5th @ W Jefferson, walk to W Jefferson @ S 6th, take the line 10 bus to W Broadway @ S 10th, walk to Louisville, KY, take the bus to Evansville, IN, take the bus to St Louis Bus Station, walk to CIVIC CENTER station, take the train to NORTH HANLEY station, walk to St. Louis, take the shuttle to Hannibal, then take the taxi to Hannibal. Alternatively, you can take a vehicle from Lexington to Hannibal via Middletown Station @ Target, S 5th @ W Jefferson, S Roy Wilkins @ W Muhammad Ali, W Broadway @ S 10th, Louisville, KY, Lafayette Amtrak Station, Lafayette Amtrak Station, Chicago Union Station, and Quincy Amtrak Station in around 17h 53m.

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