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How to get fromLexington to Kirksvilleby car, plane, bus, train, or shuttle

Find Transport to Kirksville

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There are 7 ways to get from Lexington to Kirksville by car, plane, bus, train, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Louisville International Airport, fly to Kirksville Regional Airport

    best
    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Kirksville Regional Airport (IRK)plane plane SDF - IRK
    7h 6m
    $129–516

  2. Drive 542 mi

    cheapest
    1. Drive from Lexington to Kirksvillecar car 542 mi
    9h 29m
    $99–143

  3. Bus, train

    1. Take the bus from Lexington Bus Stop to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train
    15h 59m

  4. Bus, train via Chicago

    1. Take the bus from Lexington Bus Stop to Cincinnati Bus Stationbus bus
    2. Take the bus from Cincinnati Bus Station to Indianapolis Union Stationbus bus
    3. Take the train from Indianapolis to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to La Plata Stationtrain train
    17h 1m

  5. Fly Blue Grass Airport to Columbia Regional Airport, shuttle

    1. Fly from Blue Grass Airport (LEX) to Columbia Regional Airport (COU)plane plane LEX - COU
    2. Take a shuttle bus from Columbia to Hy-Vee - Kirksvilleshuttle bus
    9h 59m
    $156–623

  6. Fly Blue Grass Airport to Kirksville Regional Airport

    1. Fly from Blue Grass Airport (LEX) to Kirksville Regional Airport (IRK)plane plane LEX - IRK
    8h 33m
    $137–597

  7. Bus, train via Centre Parkway @ 1349

    1. Take the bus from Lexington Bus Stop to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train
    16h 22m

Louisville International Airport (SDF) to Kirksville Regional Airport (IRK) flights

Calendar25Weekly Planes
Duration7h 48mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from Lexington to Kirksville.ExpandLaunch map view
  • Distance: 474.2 mi
  • Duration: 7h 6m

What companies run services between Lexington, KY, USA and Kirksville, MO, USA?

American Airlines, Corporate Flight Management Inc, and Delta fly from Blue Grass Airport (LEX) to Kirksville Regional Airport (IRK) 4 times a day.

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