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How to get fromLexington to La Crosseby car, plane, bus, or train

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There are 6 ways to get from Lexington to La Crosse by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Louisville International Airport, fly

    best
    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to La Crosse (LSE)plane plane SDF - LSE
    6h 29m
    $108–464

  2. Bus, train via Indianapolis

    1. Take the bus from Lexington Bus Stop to Cincinnati Bus Stationbus bus
    2. Take the bus from Cincinnati Bus Station to Indianapolis Union Stationbus bus
    3. Take the train from Indianapolis to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    16h 50m

  3. Bus, train

    1. Take the bus from Lexington Bus Stop to Chicago Bus Stationbus bus Greyhound US0120
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    18h 6m

  4. Drive 644.5 mi

    1. Drive from Lexington to La Crossecar car 644.5 mi
    11h 13m
    $118–170

  5. Fly from Blue Grass Airport

    1. Fly from Blue Grass Airport (LEX) to La Crosse (LSE)plane plane LEX - LSE
    8h 37m
    $116–575

  6. Bus

    1. Take the bus from Lexington Bus Stop to Chicago Bus Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to La Crossebus bus
    19h 50m

Louisville International Airport (SDF) to La Crosse (LSE) flights

Calendar35Weekly Planes
Duration5h 45mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Lexington to La Crosse.ExpandLaunch map view
  • Distance: 573.3 mi
  • Duration: 6h 29m

What companies run services between Lexington, KY, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Blue Grass Airport (LEX) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Centre Parkway @ 1349 to La Crosse via Transit Center, Walmart @ Northpark, Lexington Bus Stop, Chicago Bus Station, W Jackson Blvd, after S Clinton St, and Madison in around 19h 50m.

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