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How to get fromLexington to La Crosseby car, plane, bus, or train

Find Transport to La Crosse

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There are 8 ways to get from Lexington to La Crosse by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Covington, fly

    best
    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to La Crosse (LSE)plane plane CVG - LSE
    6h 13m
    $114–545

  2. Fly from Blue Grass Airport

    cheapest
    1. Fly from Blue Grass Airport (LEX) to La Crosse (LSE)plane plane LEX - LSE
    7h 37m
    $81–395

  3. Drive, bus, train

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus
    3. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    16h
    $119–268

  4. Drive, bus, train via Lafayette (Amtrak)

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Lafayette Amtrak Stationbus bus
    3. Take the train from Lafayette Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train
    18h 1m
    $138–318

  5. Drive  644.5 mi

    1. Drive from Lexington to La Crossecar car 644.5 mi
    11h 13m
    $118–170

  6. Drive to Louisville International Airport, fly

    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to La Crosse (LSE)plane plane SDF - LSE
    6h 29m
    $108–514

  7. Drive, bus

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to La Crossebus bus
    17h 12m
    $117–195

  8. Drive, bus via Bloomington

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville Bus Station to Bloomingtonbus bus
    3. Take the bus from Bloomington to Chicago Bus Stationbus bus
    4. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    5. Take the bus from Madison to La Crossebus bus
    19h 37m
    $117–209

Covington (CVG) to La Crosse (LSE) flights

Calendar41Weekly Planes
Duration5h 58mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to La Crosse.ExpandLaunch map view
  • Distance: 566.3 mi
  • Duration: 6h 13m

What companies run services between Lexington, KY, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Blue Grass Airport (LEX) to La Crosse (LSE) 5 times a day.

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