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How to get fromLexington to Mayo Clinicby car, plane, bus, or train

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There are 8 ways to get from Lexington to Mayo Clinic by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Covington, fly to Rochester

    best
    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Rochester (RST)plane plane CVG - RST
    6h 35m
    $106–612

  2. Fly Blue Grass Airport to Rochester

    cheapest
    1. Fly from Blue Grass Airport (LEX) to Rochester (RST)plane plane LEX - RST
    9h 3m
    $68–422

  3. Drive, bus

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    19h 37m
    $139–213

  4. Drive  709.6 mi

    1. Drive from Lexington to Mayo Cliniccar car 709.6 mi
    12h 15m
    $130–188

  5. Drive to Louisville International Airport, fly to Rochester

    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Rochester (RST)plane plane SDF - RST
    6h 57m
    $100–551

  6. Drive to Covington, fly to Minneapolis–Saint Paul International Airport, bus

    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Minneapolis–Saint Paul International Airport (MSP)plane plane CVG - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 36m
    $515–1,172

  7. Drive to Louisville International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SDF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 55m
    $174–721

  8. Drive, bus, train

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    20h 55m
    $312–473

Covington (CVG) to Rochester (RST) flights

Calendar48Weekly Planes
Duration5h 5mAverage Duration
Ticket$91Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Lexington to Mayo Clinic.ExpandLaunch map view
  • Distance: 617 mi
  • Duration: 6h 35m

What companies run services between Lexington, KY, USA and Mayo Clinic, MN, USA?

American Airlines and Delta fly from Blue Grass Airport (LEX) to Rochester (RST) every 4 hours.

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