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How to get fromLexington to Mayo Clinicby car, plane, bus (Greyhound, Flixbus), bus, or train

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There are 8 ways to get from Lexington to Mayo Clinic by car, plane, bus (Greyhound, Flixbus), bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Louisville International Airport, fly to Rochester

    best
    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Rochester (RST)plane plane SDF - RST
    6h 58m
    $94–451

  2. Bus

    1. Take the bus from Lexington Bus Stop to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    21h 26m

  3. Bus, train

    1. Take the bus from Lexington Bus Stop to Cincinnati Bus Stationbus bus
    2. Take the bus from Cincinnati Bus Station to Indianapolis Union Stationbus bus
    3. Take the train from Indianapolis to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    5. Take the bus from St. Paul to Rochester, MNbus bus
    22h

  4. Drive 709.6 mi

    1. Drive from Lexington to Mayo Cliniccar car 709.6 mi
    12h 16m
    $130–188

  5. Drive to Louisville International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SDF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 32m
    $166–623

  6. Fly Blue Grass Airport to Rochester

    1. Fly from Blue Grass Airport (LEX) to Rochester (RST)plane plane LEX - RST
    8h 34m
    $102–552

  7. Bus via Lake Delton

    1. Take the bus from Lexington Bus Stop to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Wisconsin Dellsbus bus
    3. Take the bus from Wisconsin Dells to Rochester, MNbus bus
    21h 49m

  8. Bus #2

    1. Take the bus from Lexington Bus Stop to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Saint Paul Union Depotbus bus
    3. Take the bus from St. Paul to Rochester, MNbus bus
    23h 21m

Louisville International Airport (SDF) to Rochester (RST) flights

Calendar43Weekly Planes
Duration5h 15mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Lexington to Mayo Clinic.ExpandLaunch map view
  • Distance: 617.2 mi
  • Duration: 6h 58m

What companies run services between Lexington, KY, USA and Mayo Clinic, MN, USA?

You can take a bus from Tates Creek @ Gainesway to Mayo Clinic via Transit Center, Walmart @ Northpark, Lexington Bus Stop, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 21h 26m. Alternatively, United Airlines, American Airlines, and Delta fly from Blue Grass Airport (LEX) to Rochester (RST) every 4 hours.

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