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How to get fromLexington to Missouriby car, plane, bus, or train

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There are 8 ways to get from Lexington to Missouri by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to John Glenn Columbus International Airport, fly to Lambert–St. Louis International Airport

    best
    1. Drive from Lexington to Columbus-Airport-CMHcar car
    2. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    5h 39m
    $140–706

  2. Fly Blue Grass Airport to Lambert–St. Louis International Airport

    cheapest
    1. Fly from Blue Grass Airport (LEX) to Lambert–St. Louis International Airport (STL)plane plane LEX - STL
    7h 49m
    $90–555

  3. Drive, bus

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    15h 31m
    $118–268

  4. Drive  583.9 mi

    1. Drive from Lexington to Kansas Citycar car 583.9 mi
    9h 56m
    $107–154

  5. Fly Blue Grass Airport to Columbia Regional Airport

    1. Fly from Blue Grass Airport (LEX) to Columbia Regional Airport (COU)plane plane LEX - COU
    7h 27m
    $117–457

  6. Fly Blue Grass Airport to Springfield-Branson National Airport

    1. Fly from Blue Grass Airport (LEX) to Springfield-Branson National Airport (SGF)plane plane LEX - SGF
    7h 31m
    $93–432

  7. Drive, bus, train

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    4. Take the train from St. Louis to Kansas Citytrain train
    17h 23m
    $228–438

  8. Drive, bus, train via Chicago (Amtrak)

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    3. Take the train from Chicago Union Station to Kansas Citytrain train
    18h 26m
    $304–453

John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL) flights

Calendar33Weekly Planes
Duration2h 17mAverage Duration
Ticket$101Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Missouri.ExpandLaunch map view
  • Distance: 623.5 mi
  • Duration: 5h 39m

What companies run services between Lexington, KY, USA and Missouri, USA?

United Airlines and American Airlines fly from Blue Grass Airport (LEX) to Columbia Regional Airport (COU) every 4 hours.

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