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How to get fromLexington to Santeeby car, plane, bus, train, or taxi

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There are 6 ways to get from Lexington to Santee by car, plane, bus, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Covington, fly to Charleston International Airport, drive

    best
    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Charleston International Airport (CHS)plane plane CVG - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    4h 13m
    $144–787

  2. Fly Blue Grass Airport to Columbia, drive

    cheapest
    1. Fly from Blue Grass Airport (LEX) to Columbia (CAE)plane plane LEX - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    7h 27m
    $62–357

  3. Drive, bus, train, taxi (Amtrak)

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    3. Take the train from Chicago Union Station to Denmark Amtrak Stationtrain train
    4. Take the taxi from Denmark Amtrak Station to Santeetaxi taxi
    41h 39m
    $904–1,463

  4. Drive  461.3 mi

    1. Drive from Lexington to Santeecar car 461.3 mi
    8h 48m
    $82–118

  5. Drive to Louisville International Airport, fly to Charleston International Airport, drive

    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Charleston International Airport (CHS)plane plane SDF - CHS
    3. Drive from Charleston-Airport-CHS to Santeecar car
    4h 10m
    $109–586

  6. Fly Blue Grass Airport to Charleston International Airport, drive

    1. Fly from Blue Grass Airport (LEX) to Charleston International Airport (CHS)plane plane LEX - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    7h 36m
    $77–428

Covington (CVG) to Charleston International Airport (CHS) flights

Calendar45Weekly Planes
Duration3h 27mAverage Duration
Ticket$123Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lexington to Santee.ExpandLaunch map view
  • Distance: 639.7 mi
  • Duration: 4h 13m

What companies run services between Lexington, KY, USA and Santee, SC, USA?

There is no direct connection from Lexington to Santee. However, you can drive to Covington (CVG) airport, fly to Charleston International Airport (CHS), then drive to Santee. Alternatively, you can drive to Middletown Station @ Target, take the line 31 bus to S 5th @ W Jefferson, walk to W Jefferson @ S 6th, take the line 10 bus to W Broadway @ S 10th, walk to Louisville, KY, take the bus to Chicago Union Station, walk to Chicago Union Station, take the train to Denmark Amtrak Station, then take the taxi to Santee.

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