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How to get fromLexington to Sikestonby car, bus, plane, or taxi

Find Transport to Sikeston

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There are 5 ways to get from Lexington to Sikeston by car, bus, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus via Nashville

    best
    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Nashvillebus bus
    3. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    4. Drive from Paducah Bus Station to Sikestoncar car
    11h 45m
    $76–125

  2. Drive 318.1 mi

    cheapest
    1. Drive from Lexington to Sikestoncar car 318.1 mi
    5h 30m
    $59–84

  3. Fly, drive

    1. Fly from Blue Grass Airport (LEX) to Barkley Regional Airport (PAH)plane plane LEX - PAH
    2. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    11h 1m
    $112–567

  4. Drive, bus, taxi

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    5. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    14h 11m
    $183–283

  5. Drive, bus

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from La Tropicana - Louisville, KY to Tornado Bus Co - West Memphisbus bus
    3. Take the bus from Tornado Bus Co - West Memphis to Flying J - Matthewsbus bus
    15h 31m
    $163–393

Blue Grass Airport (LEX) to Barkley Regional Airport (PAH) flights

Calendar19Weekly Planes
Duration7h 2mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

Map of how to get from Lexington to Sikeston.ExpandLaunch map view
  • Distance: 457.4 mi
  • Duration: 11h 45m

What companies run services between Lexington, KY, USA and Sikeston, MO, USA?

There is no direct connection from Lexington to Sikeston. However, you can drive to Middletown Station @ Target, take the line 31 bus to S 5th @ W Jefferson, walk to S Roy Wilkins @ W Muhammad Ali, take the line 10 bus to W Broadway @ S 10th, walk to Louisville, KY, take the bus to Nashville, take the bus to Paducah Bus Station, then drive to Sikeston. Alternatively, you can drive from Lexington to Sikeston in around 5h 30m.

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