There are 4 ways to get from Lexington to Tupelo by car, bus, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive, bus via Nashville
best- Drive from Lexington to Middletown Station @ Targetcar
- Take the bus from Louisville Bus Station to Nashville Bus Stationbus
- Take the bus from Nashville Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
13h 56m$96–162Fly, drive
cheapest- Fly from Blue Grass Airport (LEX) to Golden Triangle Regional Airport (GTR)plane LEX - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
8h 46m$73–389Drive 411.5 mi
- Drive from Lexington to Tupelocar 411.5 mi
8h 3m$76–109Drive, bus
- Drive from Lexington to Middletown Station @ Targetcar
- Take the bus from La Tropicana - Louisville, KY to Tornado Bus Co - West Memphisbus
- Take the bus from Memphis Bus Station to Tupelobus
16h 11m$144–191
Blue Grass Airport (LEX) to Golden Triangle Regional Airport (GTR) flights
Comparing Your Travel Options
The cheapest way to get from Lexington to Tupelo is to drive which costs $75 - $110 and takes 8h 3m.
The fastest way to get from Lexington to Tupelo is to drive which takes 8h 3m and costs $75 - $110.
The distance between Lexington and Tupelo is 576 miles. The road distance is 414 miles.
It takes approximately 13h 56m to get from Lexington to Tupelo, including transfers.
Tupelo is 1h behind Lexington. It is currently 9:30 AM in Lexington and 8:30 AM in Tupelo.
Yes, the driving distance between Lexington to Tupelo is 414 miles. It takes approximately 8h 3m to drive from Lexington to Tupelo.
There are 35+ hotels available in Tupelo.
What companies run services between Lexington, KY, USA and Tupelo, MS, USA?
There is no direct connection from Lexington to Tupelo. However, you can drive to Middletown Station @ Target, take the line 31 bus to S 5th @ W Jefferson, walk to W Jefferson @ S 6th, take the line 10 bus to W Broadway @ S 10th, walk to Louisville Bus Station, take the bus to Nashville Bus Station, take the bus to Memphis Bus Station, take the bus to Tupelo, then take the taxi to Tupelo. Alternatively, you can drive from Lexington to Tupelo in around 8h 3m.
- Website
- delta.com
Flights from Blue Grass Airport to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $60–370
Flights from Blue Grass Airport to Golden Triangle Regional Airport via Detroit, Atlanta
- Ave. Duration
- 7h 28m
- When
- Every day
- Estimated price
- $95–480
Flights from Blue Grass Airport to Golden Triangle Regional Airport via Reagan Washington, Atlanta
- Ave. Duration
- 8h 48m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–500
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Louisville Bus Station to Nashville Bus Station
- Ave. Duration
- 2h 55m
- Frequency
- Every 4 hours
- Estimated price
- $27–45
- Website
- Greyhound
Bus from Nashville Bus Station to Memphis Bus Station
- Ave. Duration
- 3h 20m
- Frequency
- 4 times a day
- Estimated price
- $30–55
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
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