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How to get fromLexington to Winston-Salemby car, plane, bus, or train

Find Transport to Winston-Salem

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There are 9 ways to get from Lexington to Winston-Salem by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Louisville International Airport, fly to Charlotte Douglas International Airport, bus

    best
    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Charlotte Douglas International Airport (CLT)plane plane SDF - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 10m
    $125–697

  2. Drive  348.1 mi

    cheapest
    1. Drive from Lexington to Winston-Salemcar car 348.1 mi
    7h 2m
    $64–92

  3. Drive, bus

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Columbusbus bus
    4. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    22h 36m
    $130–228

  4. Fly Blue Grass Airport to Piedmont Triad International Airport

    1. Fly from Blue Grass Airport (LEX) to Piedmont Triad International Airport (GSO)plane plane LEX - GSO
    7h 31m
    $121–725

  5. Drive to Covington, fly to Charlotte Douglas International Airport, bus

    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Charlotte Douglas International Airport (CLT)plane plane CVG - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 15m
    $131–748

  6. Drive to Tri-State Airport, fly to Charlotte Douglas International Airport, bus

    1. Drive from Lexington to Tri-State Airport (HTS)car car
    2. Fly from Tri-State Airport (HTS) to Charlotte Douglas International Airport (CLT)plane plane HTS - CLT
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 34m
    $103–507

  7. Drive to Covington, fly to Raleigh-Durham International Airport, bus

    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Raleigh-Durham International Airport (RDU)plane plane CVG - RDU
    3. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    7h 14m
    $129–699

  8. Fly Blue Grass Airport to Charlotte Douglas International Airport, bus

    1. Fly from Blue Grass Airport (LEX) to Charlotte Douglas International Airport (CLT)plane plane LEX - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    7h 40m
    $83–488

  9. Drive, bus, train

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Nashvillebus bus
    3. Take the bus from Nashville Bus Station to Lynchburg Transit Centerbus bus
    4. Take the train from Lynchburg to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    22h 55m
    $183–305

Louisville International Airport (SDF) to Charlotte Douglas International Airport (CLT) flights

Calendar58Weekly Planes
Duration2h 12mAverage Duration
Ticket$99Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Lexington to Winston-Salem.ExpandLaunch map view
  • Distance: 499.3 mi
  • Duration: 6h 10m

What companies run services between Lexington, KY, USA and Winston-Salem, NC, USA?

American Airlines, Delta, and United Airlines fly from Blue Grass Airport (LEX) to Piedmont Triad International Airport (GSO) hourly.

Airlines
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