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How to get fromLisle to Louisvilleby train, plane, bus, bus (Greyhound, Flixbus), car, or bus (Amtrak)

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There are 7 ways to get from Lisle to Louisville by train, plane, bus, bus (Greyhound, Flixbus), car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Chicago Midway International Airport, fly to Louisville International Airport

    best
    1. Take the train from Lisle to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    5h 20m
    $93–614

  2. Bus

    cheapest
    1. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    10h 15m
    $47–103

  3. Train, bus

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus Greyhound US0100 / ...
    9h 42m
    $77–171

  4. Drive  307.8 mi

    1. Drive from Lisle to Louisvillecar car 307.8 mi
    5h 26m
    $57–82

  5. Train to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the train from Lisle to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    5h 41m
    $73–454

  6. Train to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the train from Lisle to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 52m
    $60–320

  7. Bus via Lafayette (Amtrak)

    1. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus Chicago
    2. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus Chicago
    10h 18m
    $58–101

Lisle to Louisville by train and bus

Calendar3Weekly Services
Duration9h 42mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

Map of how to get from Lisle to Louisville.ExpandLaunch map view
  • Distance: 314 mi
  • Duration: 5h 20m

What companies run services between Lisle, IL, USA and Louisville, KY, USA?

Greyhound USA operates a bus from Chicago Bus Station to Louisville Bus Station 4 times a day. Tickets cost $45–95 and the journey takes 6h 5m. Flixbus USA also services this route twice daily.

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