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How to get fromLisle to Louisvilleby bus (Greyhound, Amtrak), train, bus, car, or plane

Find Transport to Louisville

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There are 7 ways to get from Lisle to Louisville by bus (Greyhound, Amtrak), train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    8h 37m
    $56–106

  2. Train, bus (Amtrak)

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    10h 17m
    $87–181

  3. Drive 307.8 mi

    1. Drive from Lisle to Louisvillecar car 307.8 mi
    5h 26m
    $57–82

  4. Line 330 bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from La Grange/Burlington Ave. to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    5h 17m
    $74–425

  5. Train to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the train from Lisle to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    5h 20m
    $88–564

  6. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 26m
    $121–681

  7. Fly Chicago O'Hare International Airport to Covington, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Covington (CVG)plane plane ORD - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    7h 49m
    $169–859

Lisle to Louisville by train, foot, and bus

Calendar14Weekly Services
Duration8h 37mAverage Duration
Ticket$56Cheapest Price
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Questions & Answers

Map of how to get from Lisle to Louisville.ExpandLaunch map view
  • Distance: 319.5 mi
  • Duration: 8h 37m

What companies run services between Lisle, IL, USA and Louisville, KY, USA?

You can take a train from Lisle to Louisville, KY via Union Station, Chicago Bus Station, and Indianapolis Union Station in around 8h 37m.

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Train operators
Bus operators

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