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How to get fromLisle to Mayo Clinicby bus, plane, train, car, subway, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Lisle to Mayo Clinic by bus, plane, train, car, subway, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 330 bus to Chicago O'Hare International Airport, fly to Rochester

    best
    1. Take the bus from La Grange/Burlington Ave. to Rosemont CTA Stationbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 23m
    $53–302

  2. Train, bus via Milwaukee

    1. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    10h 15m
    $102–166

  3. Train, bus

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochester, MNbus bus Minneapolis / ...
    12h 7m
    $163–316

  4. Drive 335.5 mi

    1. Drive from Lisle to Mayo Cliniccar car 335.5 mi
    5h 46m
    $62–89

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 58m
    $280–464

  6. Train, subway to Chicago Midway International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the train from Lisle to Chicago Union Stationtrain train
    2. Take the subway from LaSalle/Van Buren to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    4. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 21m
    $134–543

  7. Bus

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson 966 / ...
    10h 18m
    $79–133

  8. Bus via Lake Delton

    1. Take the bus from Chicago Bus Station to Wisconsin Dellsbus bus Greyhound US0150
    2. Take the bus from Wisconsin Dells to Rochester, MNbus bus Milwaukee
    10h 50m
    $80–136

Lisle to Mayo Clinic by train, bus, and foot

Calendar21Weekly Services
Duration12h 7mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Lisle to Mayo Clinic.ExpandLaunch map view
  • Distance: 303.6 mi
  • Duration: 5h 23m

What companies run services between Lisle, IL, USA and Mayo Clinic, MN, USA?

You can take a train from Lisle to Mayo Clinic via LaGrange Road, La Grange/Burlington Ave., Multi-Modal/Rental Car Facility, Madison, and Rochester in around 10h 18m.

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