There are 6 ways to get from Lisse to Brussels by bus, train, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Line 361 bus, train
best- Take the bus from Lisse, Centrum to Schiphol, Airport/Plazabus 361
- Take the train from Schiphol Airport to Brussel-Zuid / Bruxelles-Miditrain Thalys
3h 6m€81–128Train
cheapest- Take the train from Rotterdam Centraal to Bruxelles-Centraltrain Ec / ...
3h 37m€22–59Bus
- Take the bus from Amsterdam Sloterdijk to Brussels-North train stationbus 810 / ...
4h 36m€28–40Drive 189.6 km
- Drive from Lisse to Brusselscar 189.6 km
2h 24m€41–58Fly
- Fly from Amsterdam Airport Schiphol (AMS) to Brussels Airport (BRU)plane AMS - BRU
2h 29m€138–302Train via Brussel-Zuid
- Take the train from Rotterdam Centraal to Brussel-Zuidtrain EuroCity / ...
3h 42m€22–49
Lisse to Brussels by bus and train
Comparing Your Travel Options
The cheapest way to get from Lisse to Brussels is to train via Brussel-Zuid which costs €22 - €50 and takes 3h 42m.
The fastest way to get from Lisse to Brussels is to drive which takes 2h 24m and costs €40 - €60.
No, there is no direct bus from Lisse to Brussels station. However, there are services departing from Lisse, Centrum and arriving at Brussels-North train station via Schiphol, Schiphol Airport/Plaza and Amsterdam Sloterdijk. The journey, including transfers, takes approximately 4h 36m.
No, there is no direct train from Lisse to Brussels. However, there are services departing from Leiden Centraal and arriving at Bruxelles-Central via Rotterdam Centraal. The journey, including transfers, takes approximately 3h 37m.
The distance between Lisse and Brussels is 215 km. The road distance is 189.6 km.
The best way to get from Lisse to Brussels without a car is to line 361 bus and train which takes 3h 6m and costs €80 - €130.
It takes approximately 3h 6m to get from Lisse to Brussels, including transfers.
Lisse to Brussels bus services, operated by FlixBus, depart from Amsterdam Sloterdijk station.
Lisse to Brussels train services, operated by Belgian Railways (NMBS/SNCB), depart from Rotterdam Centraal station.
The best way to get from Lisse to Brussels is to bus which takes 4h 36m and costs €28 - €40. Alternatively, you can fly, which costs €130 - €310 and takes 2h 29m, you could also train, which costs €22 - €60 and takes 3h 37m.
What companies run services between Lisse, Netherlands and Brussels, Belgium?
FlixBus operates a bus from Amsterdam Sloterdijk to Brussels-North train station hourly. Tickets cost €18–27 and the journey takes 2h 45m. Alternatively, KLM flies from Amsterdam Airport Schiphol (AMS) to Brussels Airport (BRU) 4 times a day.
- Website
- klm.com
Flights from Amsterdam Airport Schiphol to Brussels Airport
- Ave. Duration
- 43 min
- When
- Every day
- Estimated price
- €40–310
- Phone
- +44 (0)3432 186 186
- Website
- Eurostar
Train from Schiphol Airport to Brussel-Zuid / Bruxelles-Midi
- Ave. Duration
- 1h 39m
- Frequency
- Hourly
- Estimated price
- €75–120
- Website
- Eurostar
- Phone
- +32 70 79 79 79
- Website
- Belgian Railways
Train from Rotterdam Centraal to Bruxelles-Central
- Ave. Duration
- 2h 2m
- Frequency
- Hourly
- Estimated price
- €28–45
- Website
- Belgian Railways
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Rotterdam Centraal to Bruxelles-Central
- Ave. Duration
- 2h 2m
- Frequency
- Hourly
- Estimated price
- €16–35
- Website
- Nederlandse Spoorwegen (NS)
Train from Rotterdam Centraal to Brussel-Zuid
- Ave. Duration
- 2h 7m
- Frequency
- Every 30 minutes
- Estimated price
- €17–35
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- +31302035833
- [email protected]
- Website
- European Sleeper
Train from Rotterdam Centraal to Bruxelles-Central
- Ave. Duration
- 2h 14m
- Frequency
- Twice a week
- Estimated price
- €13–28
- Website
- European Sleeper
Train from Rotterdam Centraal to Brussel-Zuid
- Ave. Duration
- 2h 19m
- Frequency
- Twice a week
- Estimated price
- €13–29
- Website
- European Sleeper
- Phone
- +31 900 0155
- Website
- Qbuzz B.V.
Bus from Lisse, Centrum to Schiphol, Airport/Plaza
- Ave. Duration
- 34 min
- Frequency
- Hourly
- Estimated price
- €6–8
- Website
- Qbuzz B.V.
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Amsterdam Sloterdijk to Brussels-North train station
- Ave. Duration
- 2h 45m
- Frequency
- Hourly
- Estimated price
- €18–27
- Website
- Flixbus
Want to know more about travelling around Belgium
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Want to know more about Flixbus?
Read the travel guide
Booking & Getting There
Lisse to Brussels bus services, operated by FlixBus, arrive at Brussels-North train station.
Lisse to Brussels train services, operated by Belgian Railways (NMBS/SNCB), arrive at Bruxelles-Central station.
Yes, the driving distance between Lisse to Brussels is 190 km. It takes approximately 2h 24m to drive from Lisse to Brussels.
There are 1700+ hotels available in Brussels.

























