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How to get fromLittle Rock to Mayo Clinicby plane, bus, train, or car

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There are 6 ways to get from Little Rock to Mayo Clinic by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Bill And Hillary Clinton National Airport (LIT) to Rochester (RST)plane plane LIT - RST
    6h 7m
    $146–669

  2. Drive 756.2 mi

    cheapest
    1. Drive from Little Rock to Mayo Cliniccar car 756.2 mi
    14h 5m
    $138–200

  3. Bus

    1. Take the bus from Shell gas station - Little Rock, AR to Water & Chicago - Circle Kbus bus Milwaukee
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    22h 32m
    $191–351

  4. Train, bus via Madison

    1. Take the train from Union Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    23h 49m
    $279–538

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Bill And Hillary Clinton National Airport (LIT) to Minneapolis–Saint Paul International Airport (MSP)plane plane LIT - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 55m
    $238–871

  6. Train, bus

    1. Take the train from Union Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    25h 14m
    $362–718

Little Rock to Mayo Clinic by train, bus, and foot

Calendar10Weekly Services
Duration25h 14mAverage Duration
Ticket$362Cheapest Price
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Questions & Answers

Map of how to get from Little Rock to Mayo Clinic.ExpandLaunch map view
  • Distance: 649.7 mi
  • Duration: 6h 7m

What companies run services between Little Rock, AR, USA and Mayo Clinic, MN, USA?

American Airlines and Delta fly from Bill And Hillary Clinton National Airport (LIT) to Rochester (RST) 4 times a day. Alternatively, you can take a bus from River Cities to Mayo Clinic via WalmartBaseline, Shell gas station - Little Rock, AR, Water & Chicago - Circle K, Milwaukee, and Rochester in around 22h 32m.

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