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How to get fromLos Angeles to Otay Mesaby bus, train, tram, car, plane, or bus (Greyhound)

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There are 5 ways to get from Los Angeles to Otay Mesa by bus, train, tram, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Downtown Los Angeles to San Ysidro, CAbus bus Las Vegas / ...
    3h 37m
    $46–73

  2. Drive 136 mi

    cheapest
    1. Drive from Los Angeles to Otay Mesacar car 136 mi
    2h 25m
    $25–36

  3. Train, tram

    1. Take the train from Los Angeles to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    2. Take the tram from Old Town Station to Iris Avenue Stationtram tram Blue
    4h 5m
    $43–98

  4. Fly, tram, line 905 bus

    1. Fly from Los Angeles International Airport (LAX) to San Diego International Airport (SAN)plane plane LAX - SAN
    2. Take the tram from Civic Center Station to Iris Avenue Stationtram tram
    3. Take the bus from Iris Avenue Transit Center to Otay Mesa Rd & Cactus Rdbus bus
    4h 13m
    $174–687

  5. Bus, line 929 bus

    1. Take the bus from Los Angeles Union Station to San Diegobus bus Los Angeles
    2. Take the bus from 12th & Imperial Transit Center to Iris Avenue Transit Centerbus bus 929 / ...
    4h 36m
    $28–48

Los Angeles to Otay Mesa by bus

Calendar21Weekly Buses
Duration3h 37mAverage Duration
Ticket$46Cheapest Price
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Questions & Answers

Map of how to get from Los Angeles to Otay Mesa.ExpandLaunch map view
  • Distance: 143.4 mi
  • Duration: 3h 37m

What companies run services between Los Angeles, CA, USA and Otay Mesa, CA, USA?

Tufesa operates a bus from Downtown Los Angeles to San Ysidro, CA 3 times a day. Tickets cost $40–65 and the journey takes 2h 45m.

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