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How to get fromLouisville, KY to Chicagoby bus (Greyhound, Flixbus), bus, train, car, plane, or bus (Amtrak)

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There are 9 ways to get from Louisville, KY to Chicago by bus (Greyhound, Flixbus), bus, train, car, plane, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    6h
    $40–75

  2. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    7h 55m
    $73–164

  3. Drive  295.4 mi

    1. Drive from Louisville, KY to Chicagocar car 295.4 mi
    5h 4m
    $54–78

  4. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    1. Drive from Louisville, KY to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 48m
    $55–284

  5. Bus via Lafayette (Amtrak)

    1. Take the bus from Louisville, KY to Lafayette Amtrak Stationbus bus Nashville
    2. Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus bus Nashville
    7h
    $58–91

  6. Fly Louisville International Airport to Chicago Midway International Airport

    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    3h 54m
    $59–398

  7. Fly Louisville International Airport to Chicago O'Hare International Airport

    1. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    4h 16m
    $54–338

  8. Bus to Covington, fly to Chicago O'Hare International Airport

    1. Take the bus from Louisville to Cincinnatibus bus
    2. Fly from Covington (CVG) to Chicago O'Hare International Airport (ORD)plane plane CVG - ORD
    5h 46m
    $164–850

  9. Bus to Covington, fly to Chicago Midway International Airport

    1. Take the bus from Louisville to Cincinnatibus bus
    2. Fly from Covington (CVG) to Chicago Midway International Airport (MDW)plane plane CVG - MDW
    5h 24m
    $164–410

Louisville, KY to Chicago by bus

Calendar40Weekly Buses
Duration6hAverage Duration
Ticket$40Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville, KY to Chicago.ExpandLaunch map view
  • Distance: 298.5 mi
  • Duration: 6h

What companies run services between Louisville, KY, USA and Chicago, IL, USA?

Greyhound USA operates a bus from Louisville Bus Station to Chicago Bus Station 4 times a day. Tickets cost $45–75 and the journey takes 6h. Flixbus USA also services this route twice daily. Alternatively, Southwest Airlines flies from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW) 3 times a day.

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