Rome2Rio

How to get fromLouisville, KY to Chicagoby plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Flixbus)

Find Transport to Chicago

See all options

There are 7 ways to get from Louisville, KY to Chicago by plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Chicago Midway International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    3h 54m
    $59–408

  2. Fly Louisville International Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    4h 27m
    $49–308

  3. Bus

    1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    7h 35m
    $50–60

  4. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    7h 55m
    $121–200

  5. Drive  295.4 mi

    1. Drive from Louisville, KY to Chicagocar car 295.4 mi
    5h 4m
    $54–78

  6. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    1. Drive from Louisville, KY to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 48m
    $50–274

  7. Bus via Bloomington (Flixbus)

    1. Take the bus from Louisville Bus Station to Bloomingtonbus bus FlixBus 2512
    2. Take the bus from Bloomington to Chicago Bus Stationbus bus FlixBus 2515 / ...
    8h
    $50–76

Louisville, KY to Chicago by bus

Calendar62Weekly Buses
Duration7h 35mAverage Duration
Ticket$50Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Louisville, KY to Chicago.ExpandLaunch map view
  • Distance: 290.1 mi
  • Duration: 3h 54m

What companies run services between Louisville, KY, USA and Chicago, IL, USA?

Southwest Airlines flies from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW) 4 times a day. Alternatively, Greyhound USA operates a bus from Louisville Bus Station to Chicago Bus Station 4 times a day. Tickets cost $55–85 and the journey takes 7h 35m. Two other operators also service this route.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There