There are 8 ways to get from Louisville, KY to Chicago by bus (Greyhound, Flixbus), bus, train, car, plane, or bus (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Louisville Bus Station to Chicago Bus Stationbus FlixBus 2512 / ...
5h 40m$45–95Bus, train
- Take the bus from Louisville Bus Station to Indianapolis Union Stationbus Greyhound US0100 / ...
- Take the train from Indianapolis to Chicago Union Stationtrain Cardinal
7h 55m$83–180Drive 295.4 mi
- Drive from Louisville, KY to Chicagocar 295.4 mi
5h 4m$54–78Fly Louisville International Airport to Chicago Midway International Airport
- Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane SDF - MDW
3h 49m$54–348Bus via Lafayette (Amtrak)
- Take the bus from Louisville, KY to Lafayette Amtrak Stationbus
- Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus
7h$58–91Fly Louisville International Airport to Chicago O'Hare International Airport
- Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane SDF - ORD
4h 21m$49–298Bus to Covington, fly to Chicago Midway International Airport
- Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus
- Fly from Covington (CVG) to Chicago Midway International Airport (MDW)plane CVG - MDW
5h 28m$74–443Bus to Covington, fly to Chicago O'Hare International Airport
- Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus
- Fly from Covington (CVG) to Chicago O'Hare International Airport (ORD)plane CVG - ORD
5h 56m$164–853
Louisville, KY to Chicago by bus
Questions & Answers
The cheapest way to get from Louisville, KY to Chicago is to bus which costs $45 - $95 and takes 5h 40m.
The fastest way to get from Louisville, KY to Chicago is to fly which takes 3h 49m and costs $50 - $350.
Yes, there is a direct bus departing from Louisville Bus Station station and arriving at Chicago Bus Station station. Services depart every four hours, and operate every day. The journey takes approximately 5h 40m.
The distance between Louisville, KY and Chicago is 305 miles. The road distance is 297.1 miles.
The best way to get from Louisville, KY to Chicago without a car is to bus which takes 5h 40m and costs $45 - $95.
The bus from Louisville Bus Station to Chicago Bus Station takes 5h 40m including transfers and departs every four hours.
Louisville, KY to Chicago bus services, operated by Jefferson Lines, depart from Louisville Bus Station.
The best way to get from Louisville, KY to Chicago is to bus which takes 5h 40m and costs $45 - $95. Alternatively, you can fly, which costs $50 - $350 and takes 3h 49m.
Louisville, KY to Chicago bus services, operated by Jefferson Lines, arrive at Chicago Bus Station.
Chicago is 1h behind Louisville, KY. It is currently 3:32 AM in Louisville, KY and 2:32 AM in Chicago.
What companies run services between Louisville, KY, USA and Chicago, IL, USA?
Jefferson Lines operates a bus from Louisville Bus Station to Chicago Bus Station every 4 hours. Tickets cost $75–110 and the journey takes 5h 40m. Two other operators also service this route. Alternatively, Southwest Airlines flies from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW) 3 times a day.
- Website
- united.com
Flights from Louisville International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 42m
- When
- Every day
- Estimated price
- $45–290
Flights from Covington to Chicago O'Hare International Airport
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $50–330
- Website
- southwest.com
Flights from Louisville International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $50–340
Flights from Covington to Chicago Midway International Airport
- Ave. Duration
- 1h 7m
- When
- Every day
- Estimated price
- $60–390
- Website
- aa.com
Flights from Louisville International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 47m
- When
- Every day
- Estimated price
- $45–290
Flights from Covington to Chicago O'Hare International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $50–330
- Website
- delta.com
Flights from Louisville International Airport to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $60–350
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Indianapolis to Chicago Union Station
- Ave. Duration
- 5h
- Frequency
- 3 times a week
- Estimated price
- $60–130
- Website
- https://www.amtrak.com/home.html
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Louisville Bus Station to Chicago Bus Station
- Ave. Duration
- 5h 40m
- Frequency
- Every 4 hours
- Estimated price
- $75–110
- Book at
- https://www.jeffersonlines.com
- Adult
- $75–110
Bus from Louisville Bus Station to Indianapolis Union Station
- Ave. Duration
- 1h 55m
- Frequency
- 4 times a day
- Estimated price
- $35–50
- Book at
- https://www.jeffersonlines.com
- Adult
- $35–50
Bus from Louisville, KY Bus Station to Cincinnati - Downtown
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $30–50
- Book at
- https://www.jeffersonlines.com
- Adult
- $30–50
Bus from Louisville, KY Bus Station to Cincinnati - Downtown
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $30–50
- Book at
- https://www.jeffersonlines.com
- Adult
- $30–50
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Louisville Bus Station to Chicago Bus Station
- Ave. Duration
- 6h
- Frequency
- 4 times a day
- Estimated price
- $45–95
- Website
- https://www.greyhound.com/
Bus from Louisville Bus Station to Indianapolis Union Station
- Ave. Duration
- 1h 55m
- Frequency
- 5 times a day
- Estimated price
- $18–35
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Louisville Bus Station to Chicago Bus Station
- Ave. Duration
- 5h 10m
- Frequency
- Twice daily
- Estimated price
- $45–80
- Schedules at
- flixbus.com
Rome2Rio's guide to Amtrak Thruway
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Louisville Bus Station to Indianapolis Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $22–45
- Website
- https://www.amtrak.com/home.html
- Adult
- $22–45
Bus from Louisville, KY to Lafayette Amtrak Station
- Ave. Duration
- 3h 40m
- Frequency
- Twice daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
- Adult
- $30–50
Bus from Lafayette Amtrak Station to Chicago Union Station
- Ave. Duration
- 2h 20m
- Frequency
- Twice daily
- Estimated price
- $24–45
- Website
- https://www.amtrak.com/home.html
- Adult
- $24–45
- Phone
- +1 888-378-3823
- [email protected]
- Website
- baronsbus.com
Bus from Louisville, KY Bus Station to Cincinnati - Downtown
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $9–45
- Website
- https://baronsbus.com
Bus from Louisville, KY Bus Station to Cincinnati - Downtown
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $9–45
- Website
- https://baronsbus.com
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More Questions & Answers
Yes, the driving distance between Louisville, KY to Chicago is 297 miles. It takes approximately 5h 4m to drive from Louisville, KY to Chicago.
Book your Louisville, KY to Chicago bus tickets online with Omio and FlixBus.
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