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How to get fromLouisville, KY to Chicagoby car, plane, bus (Greyhound, Amtrak, Flixbus), bus, train, or bus (Flixbus)

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There are 7 ways to get from Louisville, KY to Chicago by car, plane, bus (Greyhound, Amtrak, Flixbus), bus, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Louisville, KY to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 48m
    $50–274

  2. Bus

    cheapest
    1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    7h 35m
    $45–80

  3. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    7h 55m
    $69–169

  4. Drive  295.4 mi

    1. Drive from Louisville, KY to Chicagocar car 295.4 mi
    5h 4m
    $54–78

  5. Fly Louisville International Airport to Chicago Midway International Airport

    1. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    3h 54m
    $64–408

  6. Fly Louisville International Airport to Chicago O'Hare International Airport

    1. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    4h 18m
    $49–338

  7. Bus via Bloomington (Flixbus)

    1. Take the bus from Louisville Bus Station to Bloomingtonbus bus FlixBus 2512
    2. Take the bus from Bloomington to Chicago Bus Stationbus bus FlixBus 2515 / ...
    8h
    $49–76

Louisville, KY to Chicago by bus

Calendar54Weekly Buses
Duration7h 35mAverage Duration
Ticket$45Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville, KY to Chicago.ExpandLaunch map view
  • Distance: 413.4 mi
  • Duration: 3h 48m

What companies run services between Louisville, KY, USA and Chicago, IL, USA?

Greyhound USA operates a bus from Louisville Bus Station to Chicago Bus Station 4 times a day. Tickets cost $45–80 and the journey takes 7h 35m. Two other operators also service this route. Alternatively, Southwest Airlines flies from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW) 3 times a day.

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