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How to get fromLouisville, KY to St. Louisby bus (Greyhound), car, plane, or bus

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There are 5 ways to get from Louisville, KY to St. Louis by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Louisville, KY to Evansville, INbus bus Louisville / ...
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus Greyhound US0186 / ...
    6h 40m
    $64–101

  2. Drive 259.1 mi

    cheapest
    1. Drive from Louisville, KY to St. Louiscar car 259.1 mi
    4h 17m
    $48–69

  3. Fly from Louisville International Airport

    1. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    6h 5m
    $105–606

  4. Bus to Nashville, fly

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Lambert–St. Louis International Airport (STL)plane plane BNA - STL
    6h 27m
    $113–528

  5. Bus to Covington, fly

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    7h 39m
    $135–748

Louisville, KY to St. Louis by bus

Calendar14Weekly Buses
Duration6h 40mAverage Duration
Ticket$64Cheapest Price
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Questions & Answers

Map of how to get from Louisville, KY to St. Louis.ExpandLaunch map view
  • Distance: 286.7 mi
  • Duration: 6h 40m

What companies run services between Louisville, KY, USA and St. Louis, MO, USA?

You can take a bus from Louisville, KY to St Louis Bus Station via Evansville Bus Station in around 6h 40m. Alternatively, Southwest Airlines, United Airlines, and two other airlines fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) hourly.

Airlines
Bus operators

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Need to know: Greyhound

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