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How to get fromLouisville to Buffaloby plane, bus, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Louisville to Buffalo by plane, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Buffalo Niagara International Airport (BUF)plane plane SDF - BUF
    6h 28m
    $123–706

  2. Bus

    cheapest
    1. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus Louisville / ...
    2. Take the bus from Cleveland, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo / ...
    11h 5m
    $53–140

  3. Drive  531.4 mi

    1. Drive from Louisville to Buffalocar car 531.4 mi
    9h 2m
    $97–141

  4. Drive to Blue Grass Airport, fly

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Buffalo Niagara International Airport (BUF)plane plane LEX - BUF
    6h 17m
    $104–572

  5. Bus to Nashville, fly

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Buffalo Niagara International Airport (BUF)plane plane BNA - BUF
    7h 39m
    $149–751

  6. Bus via Akron

    1. Take the bus from Louisville to Akronbus bus Bsb 28
    2. Take the bus from Akron to Buffalobus bus Bsb 10
    11h 35m
    $54–142

  7. Bus via Columbus

    1. Take the bus from Louisville to Columbusbus bus Bsb 28 / ...
    2. Take the bus from Columbus to Buffalobus bus FlixBus 2526
    11h 54m
    $81–139

Louisville to Buffalo by bus

Calendar14Weekly Buses
Duration11h 5mAverage Duration
Ticket$53Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Buffalo.ExpandLaunch map view
  • Distance: 508.9 mi
  • Duration: 6h 28m

What companies run services between Louisville, KY, USA and Buffalo, NY, USA?

United Airlines, Southwest Airlines, and two other airlines fly from Louisville International Airport (SDF) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Louisville, KY Bus Station to Buffalo, NY via Cleveland, OH in around 11h 5m.

Airlines
Bus operators

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