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How to get fromLouisville to Buffaloby plane, bus (Amtrak), bus, train, car, or bus (Amtrak, Greyhound, Flixbus)

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There are 10 ways to get from Louisville to Buffalo by plane, bus (Amtrak), bus, train, car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Buffalo Niagara International Airport (BUF)plane plane SDF - BUF
    6h 23m
    $127–731

  2. Bus via Cleveland

    cheapest
    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to Toledobus bus
    3. Take the bus from Toledo to Clevelandbus bus
    4. Take the bus from Cleveland to Buffalobus bus
    14h 10m
    $73–214

  3. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train
    21h 4m
    $415–804

  4. Drive  531.4 mi

    1. Drive from Louisville to Buffalocar car 531.4 mi
    9h 2m
    $97–141

  5. Drive to Blue Grass Airport, fly to Buffalo Niagara International Airport

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Buffalo Niagara International Airport (BUF)plane plane LEX - BUF
    6h 25m
    $113–597

  6. Drive to Covington, fly to Toronto Pearson International Airport, bus

    1. Drive from Louisville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Toronto Pearson International Airport (YYZ)plane plane CVG - YYZ
    3. Take the bus from Toronto Pearson Airport to Buffalobus bus
    7h 17m
    $107–518

  7. Bus to Nashville, fly to Buffalo Niagara International Airport

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Buffalo Niagara International Airport (BUF)plane plane BNA - BUF
    7h 39m
    $160–776

  8. Bus, train via Toledo

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis to Toledobus bus
    3. Take the train from Toledo to Buffalo Depew Stationtrain train
    14h 58m
    $206–499

  9. Bus, train via Toledo #2

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Toledo Bus Stopbus bus
    3. Take the train from Toledo to Buffalo Depew Stationtrain train
    15h 43m
    $222–358

  10. Bus

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Buffalobus bus
    16h 4m
    $105–177

Louisville to Buffalo by bus

Calendar7Weekly Buses
Duration14h 10mAverage Duration
Ticket$73Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Buffalo.ExpandLaunch map view
  • Distance: 508.8 mi
  • Duration: 6h 23m

What companies run services between Louisville, KY, USA and Buffalo, NY, USA?

Delta, Southwest Airlines, and two other airlines fly from Louisville International Airport (SDF) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Louisville, KY to Buffalo via Indianapolis, Toledo, and Cleveland in around 14h 10m.

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