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How to get fromLouisville to Cape Girardeauby bus (Greyhound), car, plane, taxi, bus, or train

Find Transport to Cape Girardeau

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There are 6 ways to get from Louisville to Cape Girardeau by bus (Greyhound), car, plane, taxi, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    9h 49m
    $87–145

  2. Drive 255.4 mi

    cheapest
    1. Drive from Louisville to Cape Girardeaucar car 255.4 mi
    4h 48m
    $47–68

  3. Fly to Williamson County Regional Airport, taxi

    1. Fly from Louisville International Airport (SDF) to Williamson County Regional Airport (MWA)plane plane SDF - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    7h 18m
    $212–593

  4. Bus, train, taxi

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Champaign Intermodal Trans Ctrbus bus
    3. Take the train from Champaign-Urbana to Carbondaletrain train
    4. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    10h 19m
    $196–329

  5. Fly to Barkley Regional Airport, taxi

    1. Fly from Louisville International Airport (SDF) to Barkley Regional Airport (PAH)plane plane SDF - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    8h 7m
    $227–623

  6. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    8h 45m
    $124–650

Louisville International Airport (SDF) to Williamson County Regional Airport (MWA) flights

Calendar24Weekly Planes
Duration5h 38mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Cape Girardeau.ExpandLaunch map view
  • Distance: 402.5 mi
  • Duration: 9h 49m

What companies run services between Louisville, KY, USA and Cape Girardeau, MO, USA?

You can take a bus from Louisville, KY to Cape Girardeau via Evansville Bus Station, St Louis Bus Station, and Cape Girardeau in around 9h 49m.

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