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How to get fromLouisville to Carlisleby plane, bus (Flixbus), car, train, or bus (Greyhound)

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There are 5 ways to get from Louisville to Carlisle by plane, bus (Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Harrisburg International Airport (MDT)plane plane SDF - MDT
    7h 38m
    $79–457

  2. Bus via Columbus

    cheapest
    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus Louisville
    2. Take the bus from Columbus to Harrisburg Bus Stationbus bus Greyhound US0421
    16h 51m
    $77–171

  3. Bus

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus Louisville
    2. Take the bus from Cincinnati to Harrisburg Bus Stationbus bus FlixBus N2642
    16h 21m
    $88–181

  4. Drive 551.6 mi

    1. Drive from Louisville to Carlislecar car 551.6 mi
    9h 33m
    $101–146

  5. Fly to Philadelphia International Airport, train

    1. Fly from Louisville International Airport (SDF) to Philadelphia International Airport (PHL)plane plane SDF - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    8h 53m
    $136–678

Louisville to Carlisle by bus and foot

Calendar5Weekly Services
Duration16h 21mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Carlisle.ExpandLaunch map view
  • Distance: 537.8 mi
  • Duration: 7h 38m

What companies run services between Louisville, KY, USA and Carlisle, PA, USA?

United Airlines, American Airlines, and Delta fly from Louisville International Airport (SDF) to Harrisburg International Airport (MDT) hourly. Alternatively, you can take a bus from Louisville, KY Bus Station to Hanover St & High St via Cincinnati - Downtown, 9Th St & Race St, Northside Transit Center - Shelter B, Vine St & Martin Luther King Dr, Cincinnati, Harrisburg Bus Station, and Market Square Transfer Center in around 16h 21m.

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