Rome2Rio

How to get fromLouisville to Charlestonby plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or bus (Greyhound)

Find Transport to Charleston

See all options

There are 5 ways to get from Louisville to Charleston by plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Charleston International Airport (CHS)plane plane SDF - CHS
    4h 40m
    $344–405

  2. Bus to Covington, fly

    cheapest
    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Charleston International Airport (CHS)plane plane CVG - CHS
    6h 52m
    $94–1,047

  3. Bus via Nashville

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    22h 39m
    $142–265

  4. Drive 580.9 mi

    1. Drive from Louisville to Charlestoncar car 580.9 mi
    11h 18m
    $106–154

  5. Bus

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Take the bus from Evansville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    25h 29m
    $172–315

Louisville to Charleston by bus

Calendar7Weekly Buses
Duration22h 39mAverage Duration
Ticket$142Cheapest Price
See schedules

Questions & Answers

Map of how to get from Louisville to Charleston.ExpandLaunch map view
  • Distance: 507.4 mi
  • Duration: 4h 40m

What companies run services between Louisville, KY, USA and Charleston, SC, USA?

Breeze Airways, Southwest Airlines, and two other airlines fly from Louisville International Airport (SDF) to Charleston International Airport (CHS) 5 times a day. Alternatively, you can take a bus from Louisville, KY to Transit Mall via Nashville Bus Station, Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 22h 39m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers