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How to get fromLouisville to Des Moinesby plane, bus (Greyhound, Amtrak), bus, train, or car

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There are 6 ways to get from Louisville to Des Moines by plane, bus (Greyhound, Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Louisville International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Des Moines (DSM)plane plane SDF - DSM
    5h 14m
    $159–874

  2. Bus

    cheapest
    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    12h 50m
    $93–184

  3. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    17h 26m
    $143–319

  4. Drive  580.9 mi

    1. Drive from Louisville to Des Moinescar car 580.9 mi
    9h 46m
    $106–154

  5. Drive to Blue Grass Airport, fly

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Des Moines (DSM)plane plane LEX - DSM
    5h 50m
    $140–690

  6. Bus to Covington, fly

    1. Take the bus from Louisville to Cincinnatibus bus
    2. Fly from Covington (CVG) to Des Moines (DSM)plane plane CVG - DSM
    7h 19m
    $169–916

Louisville to Des Moines by bus

Calendar7Weekly Buses
Duration12h 50mAverage Duration
Ticket$93Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Des Moines.ExpandLaunch map view
  • Distance: 491.6 mi
  • Duration: 5h 14m

What companies run services between Louisville, KY, USA and Des Moines, IA, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Louisville International Airport (SDF) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Louisville Bus Station to Des Moines via Indianapolis Union Station in around 12h 50m.

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