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How to get fromLouisville to Durhamby plane, bus, bus (Amtrak, Greyhound, Flixbus), train, car, or bus (Greyhound)

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There are 9 ways to get from Louisville to Durham by plane, bus, bus (Amtrak, Greyhound, Flixbus), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Raleigh-Durham International Airport, bus, line 700 bus

    best
    1. Fly from Louisville International Airport (SDF) to Raleigh-Durham International Airport (RDU)plane plane SDF - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    4h 25m
    $188–419

  2. Drive 497.2 mi

    cheapest
    1. Drive from Louisville to Durhamcar car 497.2 mi
    9h 29m
    $91–132

  3. Bus via Atlanta

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Downtown to Durhambus bus
    16h 34m
    $126–224

  4. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the train from Greensboro to Durham Amtrak Stationtrain train
    25h 14m
    $296–604

  5. Fly Louisville International Airport to Piedmont Triad International Airport, train

    1. Fly from Louisville International Airport (SDF) to Piedmont Triad International Airport (GSO)plane plane SDF - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    7h 21m
    $159–728

  6. Bus to Covington, fly to Raleigh-Durham International Airport

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Raleigh-Durham International Airport (RDU)plane plane CVG - RDU
    6h 39m
    $228–491

  7. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Durhambus bus
    16h 40m
    $123–241

  8. Bus #2

    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Coble Transportation Center to N Columbia St at W Franklin Stbus bus 4
    19h 33m
    $95–198

  9. Bus, train via Arlington (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Alexandriatrain train
    3. Take the train from Alexandria to Durham Amtrak Stationtrain train
    29h 4m
    $353–724

Louisville to Durham by bus and subway

Calendar5Weekly Services
Duration16h 34mAverage Duration
Ticket$126Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Durham.ExpandLaunch map view
  • Distance: 438.4 mi
  • Duration: 4h 25m

What companies run services between Louisville, KY, USA and Durham, NC, USA?

You can take a bus from Louisville, KY to Durham via Nashville Bus Station, Atlanta Bus Station, Garnett Station, Civic Center Station, and Atlanta Downtown in around 16h 34m.

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Train operators
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