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How to get fromLouisville to Durhamby plane, bus, bus (Amtrak, Greyhound, Flixbus), train, car, or bus (Amtrak, Greyhound)

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There are 9 ways to get from Louisville to Durham by plane, bus, bus (Amtrak, Greyhound, Flixbus), train, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Raleigh-Durham International Airport, line 700 bus

    best
    1. Fly from Louisville International Airport (SDF) to Raleigh-Durham International Airport (RDU)plane plane SDF - RDU
    2. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    4h 22m
    $103–609

  2. Drive  497.2 mi

    cheapest
    1. Drive from Louisville to Durhamcar car 497.2 mi
    9h 31m
    $91–132

  3. Bus via Atlanta

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Downtown to Durhambus bus
    16h 29m
    $131–204

  4. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the train from Greensboro to Durham Amtrak Stationtrain train
    25h 14m
    $473–794

  5. Drive to Covington, fly to Raleigh-Durham International Airport

    1. Drive from Louisville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Raleigh-Durham International Airport (RDU)plane plane CVG - RDU
    4h 35m
    $143–781

  6. Fly Louisville International Airport to Piedmont Triad International Airport, train

    1. Fly from Louisville International Airport (SDF) to Piedmont Triad International Airport (GSO)plane plane SDF - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    7h 8m
    $126–508

  7. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Durhambus bus
    16h 35m
    $128–221

  8. Bus #2

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    21h 35m
    $142–236

  9. Bus, train via Arlington (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Alexandriatrain train
    3. Take the train from Alexandria to Durham Amtrak Stationtrain train
    29h 4m
    $583–924

Louisville to Durham by bus and subway

Calendar4Weekly Services
Duration16h 29mAverage Duration
Ticket$131Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Durham.ExpandLaunch map view
  • Distance: 438.4 mi
  • Duration: 4h 22m

What companies run services between Louisville, KY, USA and Durham, NC, USA?

You can take a bus from Louisville, KY to Durham via Nashville Bus Station, Atlanta Bus Station, Garnett Station, Civic Center Station, and Atlanta Downtown in around 16h 29m.

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Train operators
Bus operators

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