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How to get fromLouisville to Florenceby plane, bus (Amtrak, Greyhound, Flixbus), car, or bus (Greyhound)

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There are 4 ways to get from Louisville to Florence by plane, bus (Amtrak, Greyhound, Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Louisville International Airport (SDF) to Florence Regional Airport (FLO)plane plane SDF - FLO
    5h 19m
    $82–426

  2. Bus via Atlanta

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    15h 50m
    $113–211

  3. Drive 548.2 mi

    1. Drive from Louisville to Florencecar car 548.2 mi
    10h 48m
    $100–145

  4. Bus

    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus
    2. Take the bus from Columbus - Mound St to Hurricanebus bus
    3. Take the bus from Hurricane to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Camdenbus bus
    5. Take the bus from Camden to Florence Bus Stationbus bus
    20h 45m
    $82–226

Louisville to Florence by bus

Calendar14Weekly Buses
Duration15h 50mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Florence.ExpandLaunch map view
  • Distance: 442.8 mi
  • Duration: 5h 19m

What companies run services between Louisville, KY, USA and Florence, SC, USA?

American Airlines flies from Louisville International Airport (SDF) to Florence Regional Airport (FLO) twice daily. Alternatively, you can take a bus from Louisville, KY to Florence Bus Station via Nashville Bus Station and Atlanta Bus Station in around 15h 50m.

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