Rome2Rio

How to get fromLouisville to Florida Keysby plane, bus (Greyhound, Amtrak, Flixbus), car, shuttle, bus, bus (Greyhound, Flixbus), or bus (Greyhound)

Find Transport to Florida Keys

See all options

There are 9 ways to get from Louisville to Florida Keys by plane, bus (Greyhound, Amtrak, Flixbus), car, shuttle, bus, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Key West International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)plane plane SDF - EYW
    8h 54m
    $174–587

  2. Drive to Blue Grass Airport, fly to Key West International Airport

    cheapest
    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Key West International Airport (EYW)plane plane LEX - EYW
    8h 5m
    $160–483

  3. Bus via Nashville

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    29h 5m
    $183–327

  4. Drive  1,158.1 mi

    1. Drive from Louisville to Florida Keyscar car 1,158.1 mi
    21h 43m
    $212–306

  5. Fly Louisville International Airport to Miami International Airport, shuttle

    1. Fly from Louisville International Airport (SDF) to Miami International Airport (MIA)plane plane SDF - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 32m
    $264–787

  6. Fly Louisville International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Louisville International Airport (SDF) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane SDF - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 52m
    $294–857

  7. Bus to Covington, fly to Key West International Airport

    1. Take the bus from Louisville to Cincinnatibus bus
    2. Fly from Covington (CVG) to Key West International Airport (EYW)plane plane CVG - EYW
    8h 59m
    $199–689

  8. Bus

    1. Take the bus from Louisville Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    29h 10m
    $185–324

  9. Bus via Tallahassee (Greyhound)

    1. Take the bus from Louisville Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Tallahasseebus bus
    3. Take the bus from Tallahassee to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    35h 45m
    $221–352

Louisville to Florida Keys by bus and foot

Calendar14Weekly Services
Duration29h 5mAverage Duration
Ticket$183Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Louisville to Florida Keys.ExpandLaunch map view
  • Distance: 998.2 mi
  • Duration: 8h 54m

What companies run services between Louisville, KY, USA and Florida Keys, FL, USA?

Delta, Allegiant Air, and American Airlines fly from Louisville International Airport (SDF) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Louisville Bus Station to Florida Keys via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 29h 5m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There