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How to get fromLouisville to Florida Keysby plane, bus (Amtrak, Greyhound, Flixbus), car, shuttle, or bus

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There are 8 ways to get from Louisville to Florida Keys by plane, bus (Amtrak, Greyhound, Flixbus), car, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Key West International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)plane plane SDF - EYW
    8h 40m
    $169–547

  2. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    29h 10m
    $190–375

  3. Drive 1,159.5 mi

    1. Drive from Louisville to Florida Keyscar car 1,159.5 mi
    21h 43m
    $212–306

  4. Drive to Blue Grass Airport, fly to Key West International Airport

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Key West International Airport (EYW)plane plane LEX - EYW
    8h 34m
    $190–663

  5. Fly Louisville International Airport to Miami International Airport, shuttle

    1. Fly from Louisville International Airport (SDF) to Miami International Airport (MIA)plane plane SDF - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 33m
    $254–687

  6. Fly Louisville International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Louisville International Airport (SDF) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane SDF - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 56m
    $454–1,007

  7. Bus to Covington, fly to Key West International Airport

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Key West International Airport (EYW)plane plane CVG - EYW
    9h 10m
    $189–619

  8. Bus via Tallahassee

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    33h 35m
    $215–410

Louisville to Florida Keys by bus and foot

Calendar14Weekly Services
Duration29h 10mAverage Duration
Ticket$190Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Florida Keys.ExpandLaunch map view
  • Distance: 998.2 mi
  • Duration: 8h 40m

What companies run services between Louisville, KY, USA and Florida Keys, FL, USA?

Delta, American Airlines, and Breeze Airways fly from Louisville International Airport (SDF) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a bus from Louisville, KY to Florida Keys via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 29h 10m.

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