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How to get fromLouisville to Florida Keysby car, plane, bus (Amtrak, Greyhound, Flixbus), shuttle, or bus (Amtrak, Greyhound)

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There are 8 ways to get from Louisville to Florida Keys by car, plane, bus (Amtrak, Greyhound, Flixbus), shuttle, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Covington, fly to Key West International Airport

    best
    1. Drive from Louisville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Key West International Airport (EYW)plane plane CVG - EYW
    7h
    $204–719

  2. Drive to Blue Grass Airport, fly to Key West International Airport

    cheapest
    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Key West International Airport (EYW)plane plane LEX - EYW
    8h 5m
    $150–433

  3. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    29h 5m
    $203–345

  4. Drive  1,158.1 mi

    1. Drive from Louisville to Florida Keyscar car 1,158.1 mi
    21h 43m
    $212–306

  5. Fly Louisville International Airport to Key West International Airport

    1. Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)plane plane SDF - EYW
    8h 54m
    $154–487

  6. Fly Louisville International Airport to Miami International Airport, shuttle

    1. Fly from Louisville International Airport (SDF) to Miami International Airport (MIA)plane plane SDF - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 40m
    $244–657

  7. Fly Louisville International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Louisville International Airport (SDF) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane SDF - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 52m
    $274–757

  8. Bus via Tallahassee

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    33h 15m
    $243–375

Louisville to Florida Keys by bus and foot

Calendar14Weekly Services
Duration29h 5mAverage Duration
Ticket$203Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Florida Keys.ExpandLaunch map view
  • Distance: 1,132.1 mi
  • Duration: 7h

What companies run services between Louisville, KY, USA and Florida Keys, FL, USA?

You can take a bus from Louisville, KY to Florida Keys via Nashville Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 29h 5m. Alternatively, Delta and American Airlines fly from Louisville International Airport (SDF) to Key West International Airport (EYW) every 4 hours.

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