There are 7 ways to get from Louisville to Florida Keys by plane, bus (Greyhound, Flixbus), car, shuttle, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Louisville International Airport to Key West International Airport
best- Fly from Louisville International Airport (SDF) to Key West International Airport (EYW)plane SDF - EYW
8h 28m$169–557Drive to Blue Grass Airport, fly to Key West International Airport
cheapest- Drive from Louisville to Lexington-Airport-LEXcar
- Fly from Blue Grass Airport (LEX) to Key West International Airport (EYW)plane LEX - EYW
8h 28m$160–463Bus
- Take the bus from Louisville Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
29h 10m$184–394Drive 1,158.1 mi
- Drive from Louisville to Florida Keyscar 1,158.1 mi
21h 43m$212–306Fly Louisville International Airport to Miami International Airport, shuttle
- Fly from Louisville International Airport (SDF) to Miami International Airport (MIA)plane SDF - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
9h 30m$264–787Bus to Covington, fly to Key West International Airport
- Take the bus from Louisville to Cincinnatibus
- Fly from Covington (CVG) to Key West International Airport (EYW)plane CVG - EYW
9h 5m$189–629Fly Louisville International Airport to Fort Lauderdale–Hollywood International Airport, shuttle
- Fly from Louisville International Airport (SDF) to Fort Lauderdale–Hollywood International Airport (FLL)plane SDF - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
9h 58m$294–857
Louisville to Florida Keys by bus and foot
Questions & Answers
The cheapest way to get from Louisville to Florida Keys is to bus which costs $180 - $400 and takes 29h 10m.
The fastest way to get from Louisville to Florida Keys is to drive and fly which takes 8h 28m and costs $160 - $470.
No, there is no direct bus from Louisville station to Florida Keys. However, there are services departing from Louisville Bus Station and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Atlanta Bus Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 29h 10m.
The distance between Louisville and Florida Keys is 1004 miles. The road distance is 1164.8 miles.
The best way to get from Louisville to Florida Keys without a car is to bus which takes 29h 10m and costs $180 - $400.
It takes approximately 8h 28m to get from Louisville to Florida Keys, including transfers.
Louisville to Florida Keys bus services, operated by Greyhound USA, depart from Louisville Bus Station.
The best way to get from Louisville to Florida Keys is to fly which takes 8h 28m and costs $160 - $600. Alternatively, you can bus, which costs $180 - $400 and takes 29h 10m.
Louisville to Florida Keys bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Yes, the driving distance between Louisville to Florida Keys is 1165 miles. It takes approximately 21h 43m to drive from Louisville to Florida Keys.
What companies run services between Louisville, KY, USA and Florida Keys, FL, USA?
Delta and American Airlines fly from Louisville International Airport (SDF) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Louisville Bus Station to Florida Keys via Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 29h 10m.
- Website
- delta.com
Flights from Louisville International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $90–460
Flights from Blue Grass Airport to Key West International Airport via Atlanta
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $70–350
Flights from Covington to Key West International Airport via Atlanta
- Ave. Duration
- 5h 2m
- When
- Every day
- Estimated price
- $100–490
Flights from Louisville International Airport to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 5h 8m
- When
- Every day
- Estimated price
- $120–650
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Louisville Bus Station to Atlanta Bus Station
- Ave. Duration
- 8h 30m
- Frequency
- Every 4 hours
- Estimated price
- $65–130
- Website
- Greyhound
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 17h 20m
- Frequency
- Once daily
- Estimated price
- $110–220
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $20–40
- Website
- Greyhound
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More Questions & Answers
There are 973+ hotels available in Florida Keys.


