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How to get fromLouisville to Gainesvilleby plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or bus (Amtrak, Greyhound)

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There are 8 ways to get from Louisville to Gainesville by plane, bus (Amtrak, Greyhound, Flixbus), car, bus, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Gainesville Regional Airport

    best
    1. Fly from Louisville International Airport (SDF) to Gainesville Regional Airport (GNV)plane plane SDF - GNV
    6h 42m
    $89–475

  2. Bus via Atlanta

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    14h 40m
    $108–186

  3. Drive 703.3 mi

    1. Drive from Louisville to Gainesvillecar car 703.3 mi
    12h 59m
    $129–186

  4. Fly Louisville International Airport to Orlando, bus

    1. Fly from Louisville International Airport (SDF) to Orlando (MCO)plane plane SDF - MCO
    2. Take the bus from Orlando - RedCoach Station, FL to University of Florida - 1956 Gale Lemerand Drbus bus
    7h 15m
    $471–960

  5. Fly Louisville International Airport to Jacksonville, bus

    1. Fly from Louisville International Airport (SDF) to Jacksonville (JAX)plane plane SDF - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    9h 13m
    $102–572

  6. Fly Louisville International Airport to Tampa, bus

    1. Fly from Louisville International Airport (SDF) to Tampa (TPA)plane plane SDF - TPA
    2. Take the bus from Tampa Bus Station to Gainesvillebus bus
    7h 45m
    $122–584

  7. Drive to Blue Grass Airport, fly to Orlando Sanford, drive

    1. Drive from Louisville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Orlando Sanford (SFB)plane plane LEX - SFB
    3. Drive from Orlando-Sanford-Airport-SFB to Gainesvillecar car
    5h 38m
    $103–439

  8. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Gainesville Bus Stopbus bus
    18h 58m
    $120–218

Louisville to Gainesville by bus

Calendar14Weekly Buses
Duration14h 40mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Gainesville.ExpandLaunch map view
  • Distance: 633.6 mi
  • Duration: 6h 42m

What companies run services between Louisville, KY, USA and Gainesville, FL, USA?

Delta and American Airlines fly from Louisville International Airport (SDF) to Gainesville Regional Airport (GNV) every 3 hours. Alternatively, you can take a bus from Louisville, KY to Gainesville via Nashville Bus Station and Atlanta Bus Station in around 14h 40m.

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