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How to get fromLouisville to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 6 ways to get from Louisville to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport, drive

    best
    1. Fly from Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS)plane plane SDF - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 46m
    $112–719

  2. Drive 290.8 mi

    cheapest
    1. Drive from Louisville to Great Smoky Mountainscar car 290.8 mi
    6h 19m
    $54–77

  3. Bus, drive

    1. Take the bus from Louisville, KY Bus Station to N Wilson Rd & Ferrell Pl - Columbusbus bus
    2. Take the bus from Wilson & Ferrell Shell Station - Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    20h 18m
    $115–253

  4. Fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from Louisville International Airport (SDF) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane SDF - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    7h 1m
    $117–558

  5. Fly to Nashville, drive

    1. Fly from Louisville International Airport (SDF) to Nashville (BNA)plane plane SDF - BNA
    2. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    7h 6m
    $92–438

  6. Bus, train, drive

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    24h 47m
    $189–374

Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS) flights

Calendar108Weekly Planes
Duration4h 35mAverage Duration
Ticket$104Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 256.4 mi
  • Duration: 6h 46m

What companies run services between Louisville, KY, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Louisville to Great Smoky Mountains. However, you can take the line 02 bus to Louisville International Airport, walk to Louisville International Airport (SDF) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Louisville, KY Bus Station to Great Smoky Mountains via Wilson & Ferrell Shell Station - Columbus, Winston Salem(Trans Center), and Asheville, NC in around 20h 18m.

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