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How to get fromLouisville to Greenvilleby plane, bus (Amtrak, Greyhound, Flixbus), car, taxi, or bus

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There are 6 ways to get from Louisville to Greenville by plane, bus (Amtrak, Greyhound, Flixbus), car, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Louisville International Airport (SDF) to Greenville–Spartanburg International Airport (GSP)plane plane SDF - GSP
    4h 46m
    $137–648

  2. Drive 376.2 mi

    cheapest
    1. Drive from Louisville to Greenvillecar car 376.2 mi
    8h 3m
    $69–100

  3. Bus

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Take the bus from Nashville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    13h 24m
    $131–288

  4. Fly Louisville International Airport to Asheville Regional Airport, taxi

    1. Fly from Louisville International Airport (SDF) to Asheville Regional Airport (AVL)plane plane SDF - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    5h 47m
    $207–573

  5. Bus to Covington, fly to Greenville–Spartanburg International Airport

    1. Take the bus from Louisville, KY Bus Station to Cincinnati - Downtownbus bus
    2. Fly from Covington (CVG) to Greenville–Spartanburg International Airport (GSP)plane plane CVG - GSP
    5h 16m
    $167–790

  6. Bus to Nashville, fly to Greenville–Spartanburg International Airport

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Greenville–Spartanburg International Airport (GSP)plane plane BNA - GSP
    6h 7m
    $150–643

Louisville International Airport (SDF) to Greenville–Spartanburg International Airport (GSP) flights

Calendar100Weekly Planes
Duration4h 18mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Greenville.ExpandLaunch map view
  • Distance: 318.8 mi
  • Duration: 4h 46m

What companies run services between Louisville, KY, USA and Greenville, SC, USA?

Southwest Airlines, Delta, and two other airlines fly from Louisville International Airport (SDF) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from Louisville, KY to Greenville via Nashville Bus Station, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 13h 24m.

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