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How to get fromLouisville to Hannibalby bus, shuttle, train, car, or plane

Find Transport to Hannibal

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There are 6 ways to get from Louisville to Hannibal by bus, shuttle, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    3. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    10h 11m
    $82–192

  2. Drive  374.4 mi

    cheapest
    1. Drive from Louisville to Hannibalcar car 374.4 mi
    6h 21m
    $69–99

  3. Bus, train via Chicago

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train
    13h 46m
    $203–424

  4. Fly from Louisville International Airport, shuttle

    1. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    2. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    8h 7m
    $115–676

  5. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to Quincy Amtrak Stationtrain train
    10h 53m
    $158–274

  6. Bus to Nashville, fly, shuttle

    1. Take the bus from Louisville Bus Station to Nashville Bus Stationbus bus
    2. Fly from Nashville (BNA) to Lambert–St. Louis International Airport (STL)plane plane BNA - STL
    3. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    8h 58m
    $186–818

Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) flights

Calendar133Weekly Planes
Duration4h 58mAverage Duration
Ticket$98Cheapest Price
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Comparing Your Travel Options

Map of how to get from Louisville to Hannibal.ExpandLaunch map view
  • Distance: 408 mi
  • Duration: 10h 11m

What companies run services between Louisville, KY, USA and Hannibal, MO, USA?

There is no direct connection from Louisville to Hannibal. However, you can take the bus to Evansville, IN, take the bus to St Louis Bus Station, walk to CIVIC CENTER station, take the train to NORTH HANLEY station, walk to St. Louis, take the shuttle to Hannibal, then take the taxi to Hannibal. Alternatively, you can take a bus from Louisville Bus Station to Hannibal via Indianapolis Union Station, Indianapolis, Chicago Union Station, and Quincy Amtrak Station in around 13h 46m.

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