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How to get fromLouisville to Hannibalby bus, shuttle, train, car, plane, bus (Greyhound), or taxi

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There are 8 ways to get from Louisville to Hannibal by bus, shuttle, train, car, plane, bus (Greyhound), or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    3. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    10h 11m
    $98–143

  2. Drive 374.4 mi

    cheapest
    1. Drive from Louisville to Hannibalcar car 374.4 mi
    6h 21m
    $69–99

  3. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train
    14h 11m
    $243–459

  4. Fly Louisville International Airport to Lambert–St. Louis International Airport, shuttle

    1. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    2. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    8h 7m
    $136–645

  5. Bus

    1. Take the bus from Louisville, KY to Evansville, INbus bus
    2. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Quincy Public Transit Hubbus bus
    10h 45m
    $141–216

  6. Bus to Nashville, fly to Quincy Regional Airport, taxi

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Quincy Regional Airport (UIN)plane plane BNA - UIN
    3. Take the taxi from Quincy Regional Airport (UIN) to Hannibaltaxi taxi
    6h 34m
    $200–493

  7. Fly Louisville International Airport to Quincy Regional Airport, taxi

    1. Fly from Louisville International Airport (SDF) to Quincy Regional Airport (UIN)plane plane SDF - UIN
    2. Take the taxi from Quincy Regional Airport (UIN) to Hannibaltaxi taxi
    5h 18m
    $122–378

  8. Bus to Nashville, fly to Lambert–St. Louis International Airport, shuttle

    1. Take the bus from Louisville, KY to Nashvillebus bus
    2. Fly from Nashville (BNA) to Lambert–St. Louis International Airport (STL)plane plane BNA - STL
    3. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    9h 3m
    $149–560

Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) flights

Calendar106Weekly Planes
Duration5h 16mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Hannibal.ExpandLaunch map view
  • Distance: 408 mi
  • Duration: 10h 11m

What companies run services between Louisville, KY, USA and Hannibal, MO, USA?

You can take a bus from Louisville, KY to Hannibal via Evansville Bus Station, St Louis Bus Station, and Quincy Public Transit Hub in around 10h 45m.

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