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How to get fromLouisville to Hyannisby plane, bus (Greyhound), bus, train, car, or bus (Flixbus)

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There are 7 ways to get from Louisville to Hyannis by plane, bus (Greyhound), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Barnstable Municipal Airport

    best
    1. Fly from Louisville International Airport (SDF) to Barnstable Municipal Airport (HYA)plane plane SDF - HYA
    5h 46m
    $122–653

  2. Bus

    1. Take the bus from Louisville, KY Bus Station to Robert K Pfaff Transit Center - Akronbus bus
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Bostonbus bus
    4. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus
    25h 40m
    $153–328

  3. Bus, train via Cleveland

    1. Take the bus from Louisville, KY Bus Station to Cleveland Ohio Greyhound Stationbus bus
    2. Take the train from Cleveland Amtrak to Bostontrain train
    3. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus
    25h 45m
    $273–573

  4. Drive 971.8 mi

    1. Drive from Louisville to Hyanniscar car 971.8 mi
    17h 47m
    $178–257

  5. Fly to Boston Logan Airport, bus

    1. Fly from Louisville International Airport (SDF) to Boston Logan Airport (BOS)plane plane SDF - BOS
    2. Take the bus from Logan International Airport to Hyannis Transportation Centerbus bus
    6h 50m
    $125–513

  6. Bus via New York

    1. Take the bus from Louisville, KY Bus Station to Columbus - Downtown - Mound Stbus bus
    2. Take the bus from Columbus to New York Midtownbus bus
    3. Take the bus from New York Midtown to Bostonbus bus
    4. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    26h 5m
    $180–322

  7. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    4. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    32h 29m
    $425–889

Louisville to Hyannis by bus

Calendar7Weekly Buses
Duration25h 40mAverage Duration
Ticket$153Cheapest Price
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Questions & Answers

Map of how to get from Louisville to Hyannis.ExpandLaunch map view
  • Distance: 858.6 mi
  • Duration: 5h 46m

What companies run services between Louisville, KY, USA and Hyannis, MA, USA?

American Airlines, Delta, and Cape Air fly from Louisville International Airport (SDF) to Barnstable Municipal Airport (HYA) 3 times a day. Alternatively, you can take a bus from Louisville, KY Bus Station to Hyannis Transportation Center via Robert K Pfaff Transit Center - Akron, Cleveland Bus Station, Boston, and Boston South Station in around 25h 40m.

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